David F. Ackart
Colorado State University
30 Papers
114 Citations
David F. Ackart is an academic researcher from Colorado State University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 15, co-authored 25 publications.
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Papers
Copper resistance is essential for virulence of Mycobacterium tuberculosis
Frank Wolschendorf,David F. Ackart,Tej B. Shrestha,Laurel Hascall-Dove,Scott Nolan,Gyanu Lamichhane,Ying Wang,Stefan H. Bossmann,Randall J. Basaraba,Michael Niederweis +9 more
TL;DR: Evidence is provided that Cu is used by the mammalian host to control Mtb infection and that Cu resistance mechanisms are crucial for Mtb virulence, revealing an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy.
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Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis
Gopinath S. Palanisamy,Natalie M. Kirk,David F. Ackart,Crystal A. Shanley,Ian M. Orme,Randall J. Basaraba +5 more
TL;DR: It is shown that the progressive oxidative stress during experimental tuberculosis in guinea pigs is due in part to a defect in host antioxidant defenses, which, it is shown, can be partially restored with antioxidant treatment.
Cigarette Smoke Increases Susceptibility to Tuberculosis—Evidence From In Vivo and In Vitro Models
Shaobin Shang,Diane J. Ordway,Marcela Henao-Tamayo,Xiyuan Bai,Rebecca E. Oberley-Deegan,Crystal A. Shanley,Ian M. Orme,Stephanie Case,Maisha Minor,David F. Ackart,Laurel Hascall-Dove,Alida R. Ovrutsky,Pitchaimani Kandasamy,Dennis R. Voelker,Cherie Lambert,Brian M. Freed,Michael D. Iseman,Randall J. Basaraba,Edward D. Chan,Edward D. Chan +19 more
TL;DR: CS suppresses the protective immune response to M. tuberculosis in mice, human THP-1 cells, and primary human alveolar macrophages, and humans exposed to CS extract, nicotine, or acrolein.
Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis
Diane J. Ordway,Crystal A. Shanley,Megan L. Caraway,Eileen A. Orme,Daniel S. Bucy,Laurel Hascall-Dove,Marcela Henao-Tamayo,Marisa Harton,Shaobin Shang,David F. Ackart,Susan L. Kraft,Anne J. Lenaerts,Randall J. Basaraba,Ian M. Orme +13 more
TL;DR: This study shows that conventional rifampin-isoniazid-pyrazinamide chemotherapy significantly decreased the numbers of the highly virulent Erdman K01 strain of Mycobacterium tuberculosis, with most of the bacilli being eliminated in a month.
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Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity.
Brendan K. Podell,David F. Ackart,Andrés Obregón-Henao,Sarah P. Eck,Marcela Henao-Tamayo,Mike A. Richardson,Ian M. Orme,Diane J. Ordway,Randall J. Basaraba +8 more
TL;DR: The guinea pig model of type 2 diabetes-TB comorbidity mimics important features of the naturally occurring disease in humans and will be beneficial in understanding the complex pathogenesis of TB in diabetic patients and to test new strategies to improve TB and diabetes control when the two diseases occur together.
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