David Eisen
Ludwig Maximilian University of Munich
10 Papers
27 Citations
David Eisen is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: DNA repair & Peptide mass fingerprinting. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of David Eisen include Center for Integrated Protein Science Munich & University of Tübingen.
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Papers
Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors
Mark Bauer,Mark Bauer,Andrea Chicca,Marco Tamborrini,David Eisen,Raissa Lerner,Beat Lutz,Oliver Poetz,Gerd Pluschke,Jürg Gertsch +9 more
TL;DR: Pepcans are the first endogenous allosteric modulators identified for CB1 receptors and could play an important physiological role in modulating endocannabinoid signaling.
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Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)
Sandra C. Koch,Jochen Kuper,Karola L. Gasteiger,Nina Simon,Ralf Strasser,David Eisen,Simon Geiger,Sabine Schneider,Caroline Kisker,Thomas Carell +9 more
TL;DR: Two crystal structures of the DNA binding domain (DBD) of the yeast XPA homolog Rad14 bound to DNA with either a cisplatin lesion (1,2-GG) or an acetylaminofluorene adduct (AAF-dG) provide insight into the mechanism of how XPA binds to kinked and lesion-containing DNA.
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Orchestrating the Biosynthesis of an Unnatural Pyrrolysine Amino Acid for Its Direct Incorporation into Proteins Inside Living Cells
Michael Ehrlich,Michael J. Gattner,Bastien Viverge,Johanna Bretzler,David Eisen,Michael Stadlmeier,Milan Vrabel,Thomas Carell +7 more
TL;DR: The construction of an E. coli expression system able to manufacture an unnatural amino acid by artificial biosynthesis can be orchestrated with incorporation into protein by amber stop codon suppression inside a living cell.
G protein-coupled receptor quantification using peptide group-specific enrichment combined with internal peptide standard reporter calibration.
David Eisen,Hannes Planatscher,Darryl B. Hardie,Udo Kraushaar,Christopher J. Pynn,Dieter Stoll,Christoph H. Borchers,Thomas O. Joos,Oliver Poetz +8 more
TL;DR: It is demonstrated for the first time, that peptide immunoaffinity MS-based methods can render a reliable and quantitative analysis of multi-membrane spanning receptor molecules.
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Combining Ultracentrifugation and Peptide Termini Group-specific Immunoprecipitation for Multiplex Plasma Protein Analysis
Sonja Volk,Thomas D. Schreiber,David Eisen,Calvin Wiese,Hannes Planatscher,Christopher J. Pynn,Dieter Stoll,Markus F. Templin,Thomas O. Joos,Oliver Pötz +9 more
TL;DR: Ulacentrifugation coupled with immunoaffinity MS approaches presents a powerful tool for multiplexed plasma protein analysis without the requirement for demanding liquid chromatography separation techniques.
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