David E. Lowery
Pfizer
19 Papers
152 Citations
David E. Lowery is an academic researcher from Pfizer. The author has contributed to research in topics: Amyloid precursor protein & Virulence. The author has an hindex of 15, co-authored 19 publications. Previous affiliations of David E. Lowery include Case Western Reserve University.
Chat about Author
Papers
Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects
Hiroyuki Arai,Virginia M.-Y. Lee,Meridith L. Messinger,Barry D. Greenberg,David E. Lowery,John Q. Trojanowski +5 more
TL;DR: β‐APPs produced in the brain are sources of β‐APP peptides that accumulate as senile plaques in AD, and are detectable only in a limited number of nonneural tissues.
154
Cloning and Functional Expression of the First Drosophila melanogaster Sulfakinin Receptor DSK-R1
Teresa Kubiak,Martha J. Larsen,Katherine J. Burton,Carol A Bannow,Roger A. Martin,Marjorie R. Zantello,David E. Lowery +6 more
TL;DR: The cloned DSK-R1 receptor is the first functionally active Drosophila sulfakinin receptor reported to date and stresses the importance of the sulfate moiety for the biological activity of drosulfakinin.
116
Nucleotide sequence of UK and australian isolates of feline calicivirus (FCV) and phylogenetic analysis of FCVs
Mark A. Glenn,Alan D Radford,Philip C. Turner,Michael J. Carter,David E. Lowery,Dwynwen A DeSilver,Jayesh Meanger,Cindy Baulch-Brown,Malcolm J. Bennett,Rosalind M. Gaskell +9 more
TL;DR: Phylogenetic analysis suggested that, unlike some other caliciviruses, FCV isolates within the current data set fall into one diverse genogroup, and there was an overall lack of geographic or temporal clustering which may be related to the epidemiology of FCV infection in cats.
76
•Journal Article
Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.
Mitsuru Kawai,Patrick Cras,P. L. Richey,Massimo Tabaton,David E. Lowery,Patricia A. Gonzalez-DeWhitt,Barry D. Greenberg,Pierluigi Gambetti,George Perry +8 more
TL;DR: The results suggest that APP accumulates in the lysosomal system of the dystrophic neurites present in senile plaques and are consistent with a neuronal origin of the APP forming the amyloid in seniles plaques.
59
A novel signature-tagged mutagenesis system for Streptococcus suis serotype 2.
Tom Wilson,Jenifer Jeffers,Vicki Rapp-Gabrielson,Stephen Martin,Loretta K. Klein,David E. Lowery,Troy E. Fuller +6 more
TL;DR: A signature-tagged mutagenesis (STM) system for S. suis serotype 2 was developed and genes required for in vivo virulence were identified, including previously known genes essential to the virulence of other organisms.
38