David E. Lefebvre
Health Canada
24 Papers
223 Citations
David E. Lefebvre is an academic researcher from Health Canada. The author has contributed to research in topics: Immune system & Cytotoxicity. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of David E. Lefebvre include University of Ottawa & Ottawa Hospital Research Institute.
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Papers
T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3
TL;DR: The differentiation of naive T-helper cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3), which can be analyzed readily by RT-PCR using total RNA isolated from mixed cell populations or cultured splenocytes thereby providing a surrogate marker of Th1/Th2 cytokine balance under a variety of conditions.
225
Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food‐relevant nanomaterials
Susann Bellmann,David Carlander,Alessio Fasano,Dragan Momcilovic,Joseph Scimeca,W. James Waldman,Lourdes Gombau,Lyubov Tsytsikova,Richard Canady,Dora I. A. Pereira,David E. Lefebvre +10 more
TL;DR: Information is provided on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid‐based entities, and the effects of these parameters on NM integrity, physicochemical properties, and GI absorption.
129
Diabetes-Specific HLA-DR–Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody–Negative Patients With Type 1 Diabetes
Majid Mojibian,Habiba Chakir,David E. Lefebvre,Jennifer A. Crookshank,Brigitte Sonier,Erin Keely,Fraser W. Scott +6 more
TL;DR: The presence of an HLA-DR–restricted Th1 and Th17 response to WPs in a subset of patients indicates a diabetes-related inflammatory state in the gut immune tissues associated with defective oral tolerance and possibly gut barrier dysfunction.
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Dietary proteins as environmental modifiers of type 1 diabetes mellitus.
TL;DR: Evidence that the source of dietary proteins can modify diabetes outcome is examined, new approaches to identify candidate diabetes-related dietary agents are described, possible links with gut dysfunction are examined, and a multifactorial model for dietary modification of diabetes is proposed.
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Promotion of Autoimmune Diabetes by Cereal Diet in the Presence or Absence of Microbes Associated With Gut Immune Activation, Regulatory Imbalance, and Altered Cathelicidin Antimicrobial Peptide
Christopher Patrick,Christopher Patrick,Gen-Sheng Wang,David E. Lefebvre,David E. Lefebvre,Jennifer A. Crookshank,Brigitte Sonier,Chandra Eberhard,Chandra Eberhard,Majid Mojibian,Majid Mojibian,Chris R. J. Kennedy,Chris R. J. Kennedy,Stephen P. J. Brooks,Martin Kalmokoff,Mariantonia Maglio,Riccardo Troncone,Philippe Poussier,Fraser W. Scott,Fraser W. Scott +19 more
TL;DR: A cereal diet was a stronger promoter of T1D than gut microbes in association with impaired gut immune homeostasis.
63