David E. Jaffe
University of Maryland, Baltimore
8 Papers
111 Citations
David E. Jaffe is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: GABAergic & Interneuron. The author has an hindex of 6, co-authored 8 publications.
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Papers
Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons.
TL;DR: For example, this article found that mice lacking the urokinase plasminogen activator receptor (Plaur) gene have decreased parvalbumin-expressing interneurons in the medial frontal cortex, but not in the hippocampus or basal lateral amygdala in the Plaur null mouse.
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Incidence of contralateral THA after index THA for osteoarthritis.
TL;DR: High- and low-risk patients who may be candidates for bilateral THA or may rarely need a contralateral THA are defined andIndeterminate- risk patients may be managed nonoperatively and deserve further study with a larger multicenter analysis.
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Astrocyte-Mediated Hepatocyte Growth Factor/Scatter Factor Supplementation Restores GABAergic Interneurons and Corrects Reversal Learning Deficits in Mice
TL;DR: The present study demonstrates that one type of behavioral flexibility, reversal learning, is dependent upon proper numbers of GABAergic interneurons and that birth defects can be corrected by replenishing crucial growth factors.
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•Journal Article
Dilute betadine lavage reduces implant-related bacterial burden in a rabbit knee prosthetic infection model.
TL;DR: Betadine lavage as a treatment adjunct may improve component retention for acute arthroplasty infection and decrease bacterial burden in a rabbit knee infection model.
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Pulsatile Lavage of Musculoskeletal Wounds Causes Muscle Necrosis and Dystrophic Calcification in a Rat Model.
Alexander M Chiaramonti,Astor Robertson,Thao Nguyen,David E. Jaffe,E. Lex Hanna,Robert E. Holmes,William R. Barfield,William L. Fourney,Joseph P. Stains,Vincent D. Pellegrini +9 more
TL;DR: Pulsatile lavage of musculoskeletal wounds can cause irreversible insult to tissue, resulting in myonecrosis and dystrophic calcification, and the benefits and offsetting harm of pulsatilelavage (20 psi) should be considered before its routine use in the management of muscles.
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