5 Papers
David DeShazer is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Burkholderia mallei & Glanders. The author has an hindex of 5, co-authored 5 publications.
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Papers
Structural flexibility in the Burkholderia mallei genome
William C. Nierman,David DeShazer,H. Stanley Kim,Hervé Tettelin,Karen E. Nelson,Tamara Feldblyum,Ricky L. Ulrich,Catherine M. Ronning,Lauren M. Brinkac,Sean C. Daugherty,Tanja Davidsen,Robert T. DeBoy,George Dimitrov,Robert J. Dodson,A. Scott Durkin,Michelle L. Gwinn,Daniel H. Haft,Hoda Khouri,James F. Kolonay,Ramana Madupu,Yasmin Mohammoud,William C. Nelson,Diana Radune,Claudia M. Romero,Saul H Sarria,Jeremy D. Selengut,Christine Shamblin,Steven A. Sullivan,Owen White,Yan Yu,Nikhat Zafar,Liwei Zhou,Claire M. Fraser,Claire M. Fraser +33 more
TL;DR: Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a B. mallei infection.
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Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice.
TL;DR: Live attenuated strains that promote a Th1-like Ig response may serve as promising vaccine candidates against aerosol infection with B. mallei.
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Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts
Claudia M. Romero,David DeShazer,Tamara Feldblyum,Jacques Ravel,Donald E. Woods,H. Stanley Kim,Yan Yu,Catherine M. Ronning,William C. Nierman +8 more
TL;DR: The notion that genome variability upon passage is a feature of B. mallei ATCC23344, and that within a host B.mallei generates a diverse population of clones that accumulate genome sequence variation at SSR and other loci is supported.
Characterization of experimental equine glanders
Jose Lopez,John Copps,Catherine L. Wilhelmsen,Richard A. Moore,Julie Kubay,Marcel St-Jacques,Stacey Halayko,Christiaan Kranendonk,Shannon Toback,David DeShazer,David Fritz,Marina Tom,Donald E. Woods +12 more
TL;DR: Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses, and should prove to be of considerable value in ongoing studies on the pathogenesis and vaccine development for glanders.
Glanders in a military research microbiologist.
Arjun Srinivasan,Carl N. Kraus,David DeShazer,Patrice M. Becker,James D. Dick,Lisa A. Spacek,John G. Bartlett,W. Russell Byrne,David L. Thomas +8 more
TL;DR: Infection with Burkholderia mallei can cause a subcutaneous infection known as farcy or can disseminate to cause the condition known as glanders, and there were secondary, often fatal, infections in humans.