David Cotnoir-White
Université de Montréal
11 Papers
21 Citations
David Cotnoir-White is an academic researcher from Université de Montréal. The author has contributed to research in topics: Histone deacetylase & Receptor tyrosine kinase. The author has an hindex of 6, co-authored 9 publications.
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Papers
Evolution of the repertoire of nuclear receptor binding sites in genomes.
TL;DR: The presence of NR binding sites in the primate-specific Alu family of short-interspersed elements has been shown to confer transcriptional regulation by NRs to adjacent genes, although the impact on NR regulatory networks at the genome-wide scale remains to be more fully evaluated.
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Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids
Rodrigo Mendoza-Sanchez,David Cotnoir-White,Justyna Kulpa,Isabel Jutras,Joshua Pottel,Nicolas Moitessier,Sylvie Mader,James L. Gleason +7 more
TL;DR: Hybrid structures which combined structural features of the pure antiestrogens ICI-164,384 and HDACi's SAHA and entinostat in a single bifunctional molecule retained antiestrogenic andHDACi activity and were selective for Class I HDAC3 over Class II HDAC6.
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Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors
TL;DR: Luciferase (Luc) protein complementation‐based bioluminescence resonance energy transfer (BRET) assays that can directly measure recruitment of a coactivator (CoA) motif fused to yellow fluorescent protein (YFP) by specific NR dimers are developed and optimized.
Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.
Anthony F. Palermo,Marine Diennet,Mohamed El Ezzy,Benjamin M. Williams,David Cotnoir-White,Sylvie Mader,James L. Gleason +6 more
TL;DR: The hybrids were antiproliferative against ER+ MCF-7 breast cancer cells, with hybrid 28b possessing an improved activity profile compared to either 4-hydroxytamoxifen or SAHA.
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Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.
TL;DR: SUMO2 and PIASγ are identified as important transcriptional co-regulators of Nur77.
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