David Christen
ETH Zurich
15 Papers
87 Citations
David Christen is an academic researcher from ETH Zurich. The author has contributed to research in topics: Bone density & Nonlinear system. The author has an hindex of 10, co-authored 15 publications.
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Papers
Bone structure at the distal radius during adolescent growth.
Salman Kirmani,David Christen,G. Harry van Lenthe,Philip R. Fischer,Mary L. Bouxsein,Louise K. McCready,L. Joseph Melton,B. Lawrence Riggs,Shreyasee Amin,Ralph Müller,Sundeep Khosla +10 more
TL;DR: It is concluded that regional deficits in cortical bone may underlie the adolescent peak in forearm fractures, and whether these deficits are more severe in children who sustain forearm fractures or persist into later life warrants further study.
291
Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level
Friederike A. Schulte,Davide Ruffoni,Floor M. Lambers,David Christen,Duncan J. Webster,Gisela A. Kuhn,Ralph Müller +6 more
TL;DR: The experimental assessment of mechanoregulation at the tissue level does not show any evidence of a lazy zone and suggests that around 80% of all (re)modeling can be linked to the mechanical micro-environment, disclosing how mechanical stimuli at the tissues level contribute to the regulation of bone adaptation at the organ level.
Multiscale modelling and nonlinear finite element analysis as clinical tools for the assessment of fracture risk.
TL;DR: The current state of the art for multiscale modelling is presented and its potential to better predict an individual's risk of fracture in a clinical setting is assessed.
61
Towards validation of computational analyses of peri-implant displacements by means of experimentally obtained displacement maps
TL;DR: It is found that peri-implant bone displacements calculated with μFE analysis correlated well with displacements obtained from experimental SM, and the lowest R2 values were found in regions of very small displacements.
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Inverse Finite Element Modeling for Characterization of Local Elastic Properties in Image-Guided Failure Assessment of Human Trabecular Bone
Alexander Zwahlen,David Christen,Davide Ruffoni,Philipp Schneider,Werner Schmölz,Ralph Müller +5 more
TL;DR: The inverse μFE algorithm was able to iterate the heterogeneous distribution of moduli such that the resulting μFE simulations matched artificially generated and experimentally measured strains.
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