David C. Zebrowski
University of Erlangen-Nuremberg
13 Papers
4 Citations
David C. Zebrowski is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Regeneration (biology) & Centrosome. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of David C. Zebrowski include University of Medicine and Dentistry of New Jersey & Max Planck Society.
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Papers
Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration
Chi-Chung Wu,Fabian Kruse,Mohankrishna Dalvoy Vasudevarao,Jan Philipp Junker,David C. Zebrowski,Kristin Fischer,Emily S. Noël,Dominic Grün,Eugene Berezikov,Eugene Berezikov,Felix B. Engel,Alexander van Oudenaarden,Gilbert Weidinger,Jeroen Bakkers +13 more
TL;DR: It is found that genetic or chemical inhibition of BMP signaling in zebrafish reduces cardiomyocyte dedifferentiation and proliferation, ultimately compromising myocardial regeneration, while bmp2b overexpression is sufficient to enhance it.
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Cardiomyocyte Cell-Cycle Activity during Preadolescence.
Mark H. Soonpaa,David C. Zebrowski,Colin Platt,Anthony Rosenzweig,Felix B. Engel,Loren J. Field +5 more
TL;DR: It has recently been suggested that a second burst of cardiomyocyte cell-cycle activity occurs during preadolescence, between PN14 and PN18, resulting in a 40% increase in carduomyocyte number.
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The cardiomyocyte cell cycle in hypertrophy, tissue homeostasis, and regeneration.
TL;DR: The result of cardiomyocyte cell cycle activity in aging and disease and studies manipulating cardiac cell cycleActivity to promote cardiac regeneration are discussed and the relationship between ploidy and regenerative potential is focused on.
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Poly(Glycerol Sebacate)/Poly(Butylene Succinate-Butylene Dilinoleate) Fibrous Scaffolds for Cardiac Tissue Engineering
Marwa Tallawi,David C. Zebrowski,Ranjana Rai,Judith A. Roether,Dirk W. Schubert,Miroslawa El Fray,Felix B. Engel,Katerina E. Aifantis,Katerina E. Aifantis,Aldo R. Boccaccini +9 more
TL;DR: F fibrous PGS/PBS-DLA scaffolds exhibit promising characteristics as a biomaterial for cardiac patch applications as well as their physical, chemical, and mechanical properties.
Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation.
TL;DR: Challenges in evaluating adult cardiomyocyte proliferation will assist in determining 1) which regenerative factors should be pursued in large animal studies; 2) if a particular level of cell cycle regulation presents a better therapeutic target than another (e.g., mitogenic receptors vs. cyclins); and 3) which combinatorial approaches offer the greatest likelihood of success.
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