David C. Immke
Amgen
15 Papers
99 Citations
David C. Immke is an academic researcher from Amgen. The author has contributed to research in topics: Acid-sensing ion channel & TRPV1. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of David C. Immke include Oregon Health & Science University.
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Papers
AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
Narender R. Gavva,Rami Tamir,Yusheng Qu,Lana Klionsky,Tie J. Zhang,David C. Immke,Judy Wang,Dawn Zhu,Todd W. Vanderah,Frank Porreca,Elizabeth M. Doherty,Mark H. Norman,Kenneth D. Wild,Anthony W. Bannon,Jean Claude Louis,James J. S. Treanor +15 more
TL;DR: AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.
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ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons.
Derek C. Molliver,Derek C. Molliver,David C. Immke,David C. Immke,Leonardo Fierro,Leonardo Fierro,Michel Paré,Michel Paré,Frank L. Rice,Edwin W. McCleskey +9 more
TL;DR: It is suggested that co-expression of ASIC3 and CGRP, and the absence of P2X3, are distinguishing properties of a class of sensory neurons, some of which innervate blood vessels and may be muscle metaboreceptors, neurons that sense the metabolic state of muscle and can trigger pain when there is insufficient oxygen.
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Narender R. Gavva,Anthony W. Bannon,David N. Hovland,Sonya G. Lehto,Lana Klionsky,Sekhar Surapaneni,David C. Immke,Charles Henley,Leyla Arik,Annette Bak,James Davis,Nadia B. Ernst,Gal Hever,Rongzhen Kuang,Licheng Shi,Rami Tamir,Jue Wang,Weiya Wang,Gary Zajic,Dawn Zhu,Mark H. Norman,Jean-Claude Louis,Ella Magal,James J. S. Treanor +23 more
TL;DR: The in vitro and in vivo characterization of a novel and selective TRPV1 antagonist, AMG 517, and its pharmacology with that of a closely related analog, tert-butyl-2-(6-([2-(acetylamino)-1,3-benzothiazol-4-yl]oxy)pyrimidin- 4-yl)-5-(trifluoromethyl)phenylcarbamate (AMG8163) suggest that
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Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
Lana Klionsky,Rami Tamir,BaoXi Gao,Weiya Wang,David C. Immke,Nobuko Nishimura,Narender R. Gavva +6 more
TL;DR: It is concluded that both human and rat TRPA1 channels show similar AITC and noxious cold activation profiles, but TCEB compounds display species-specific differential pharmacology atTRPA1.
Structure–activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists
Vijay Keshav Gore,Vu Van Ma,Ruoyuan Yin,Joe Ligutti,David C. Immke,Elizabeth M. Doherty,Mark H. Norman +6 more
TL;DR: The identification and structure-activity relationship of a novel class of potent tetrahydroquinoline BKCa agonists, shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine, is described.
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