Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

Biodegradable endoprostheses and methods for their fabrication

Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.

Methods of fabricating stents with enhanced fracture toughness

Methods of manufacturing a radially expandable stent, including radial expansion and axial elongation of a polymer tube, are disclosed.

Method of fabricating a biaxially oriented implantable medical device

Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Some embodiments may include inducing molecular orientation by expansion of a molten annular polymer film. Other embodiments may include inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer. In certain embodiments, circumferential orientation may be induced by expansion of a polymer tube. Further embodiments may include manufacturing an implantable medical device from a biaxially oriented planar polymer film.

Method of fabricating an implantable medical device with biaxially oriented polymers

The invention provides a method of manufacturing a stent, the method comprising: disposing a polymeric tube into a cylindrical mold, the cylindrical mold having a variable diameter along a portion of the inside surface of the mold; radially expanding the tube by blowing a gas or liquid into the cylindrical mold, the outside surface of the tube conforming to the variable diameter portion of the outside surface of the mold, causing the radially expanded tube to have a variable diameter along the conformed length of the tube; and fabricating a stent from the expanded tube.

Method of fabricating a stent with features by blow molding

The invention provides a method for fabricating an implantable medical device to increase biocompatibility of the device, the method comprising: heat setting a polymer construct, wherein the polymer construct is at a temperature range of from about Tg to about 0.6(Tm - Tg) + Tg such that the set polymer construct comprises a crystalline structure having crystals at a size less than about 2 microns; and fabricating an implantable medical device from the heat set polymer construct.

Method of fabricating an implantable medical device to reduce chance of late inflammatory response

The invention provides a method for fabricating an implantable medical device to increase biocompatibility of the device, the method comprising: heat setting a polymer construct, wherein the polymer construct is at a temperature range of from about Tg to about 0.6(Tm−Tg)+Tg such that the set polymer construct comprises a crystalline structure having crystals at a size less than about 2 microns; and fabricating an implantable medical device from the heat set polymer construct.

Implantable medical device having reduced chance of late inflammatory response

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Method of fabricating an implantable medical device to reduce chance of late inflammatory response

Implantable medical device having reduced chance of late inflammatory response