David C. Ebner
California Institute of Technology
14 Papers
223 Citations
David C. Ebner is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Enantioselective synthesis & Kinetic resolution. The author has an hindex of 7, co-authored 14 publications.
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Papers
Pd-Catalyzed Enantioselective Aerobic Oxidation of Secondary Alcohols : Applications to the Total Synthesis of Alkaloids
Shyam Krishnan,Jeffrey T. Bagdanoff,David C. Ebner,Yeeman K. Ramtohul,Uttam K. Tambar,Brian M. Stoltz +5 more
TL;DR: The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation.
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A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C−H and C−C Bond Insertion Reactions
TL;DR: A convergent and enantioselective synthesis of the natural product amurensinine is described, which takes advantage of mild and selective C-H and C-C bond insertion reactions in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories.
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Palladium-catalyzed enantioselective oxidation of chiral secondary alcohols: access to both enantiomeric series.
David C. Ebner,Raissa M. Trend,Cedric Genet,Matthew J. McGrath,Peter O'Brien,Brian M. Stoltz +5 more
TL;DR: The use of a diamine to provide access to either enantiomer of a range of alcohols with good selectivity factors has been applied to the formal total synthesis of (−)-amurensinine.
A Convergent and Enantioselective Synthesis of (+)‐Amurensinine via Selective C—H and C—C Bond Insertion Reactions.
TL;DR: A convergent and enantioselective synthesis of amurensinine is described in this paper, taking advantage of mild and selective C−H and C−C bond insertion reactions, in addition to the palladium-catalyzed aerobic kinetic resolution.
The Palladium‐Catalyzed Aerobic Kinetic Resolution of Secondary Alcohols: Reaction Development, Scope, and Applications
David C. Ebner,Jeffrey T. Bagdanoff,Eric M. Ferreira,Ryan M. McFadden,Daniel D. Caspi,Raissa M. Trend,Brian M. Stoltz +6 more
TL;DR: Improved reaction conditions have permitted the successful kinetic resolution of benzylic, allylic, and cyclopropyl secondary alcohols to high enantiomeric excess with good-to-excellent selectivity factors.