David C. DeWitt
Washington State University
11 Papers
40 Citations
David C. DeWitt is an academic researcher from Washington State University. The author has contributed to research in topics: Lipid bilayer fusion & Synaptic vesicle. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of David C. DeWitt include Yale University.
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Papers
Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog.
Sotiria Tavoulari,Eleonora Margheritis,Anu Nagarajan,David C. DeWitt,Yuan-Wei Zhang,Edwin Rosado,Silvia Ravera,Elizabeth Rhoades,Lucy R. Forrest,Gary Rudnick +9 more
TL;DR: Overall, the results demonstrate that occupation of Na2 stabilizes outward-facing conformations presumably through a direct interaction between Na+ and transmembrane helices 1 and 8, whereas Na+ binding at Na1 influences conformational change through a network of intermediary interactions.
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Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
Takuhiro Sonoyama,Lukas K. J. Stadler,Mingyan Zhu,Julia M. Keogh,Elana Henning,Fuki M. Hisama,Peter Kirwan,Magdalena Jura,Beata K. Blaszczyk,David C. DeWitt,Bas Brouwers,Marko Hyvönen,Inês Barroso,Florian T. Merkle,Suzanne M. Appleyard,Gary A. Wayman,I. Sadaf Farooqi +16 more
TL;DR: In this article, a de novo missense variant in BDNF and seven rare variants in Tropomyosin receptor kinase-B were identified in a large cohort of people with severe, childhood-onset obesity.
Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase
Jennifer L. Fribourgh,Henry C. Nguyen,Leslie S. Wolfe,David C. DeWitt,Wenyan Zhang,Xiao Fang Yu,Elizabeth Rhoades,Yong Xiong +7 more
TL;DR: The results suggest that CBFβ may serve as a molecular chaperone to enable Vif to adopt an appropriate conformation for interaction with the Cul5-based E3 ligase, and advance the understanding of how CBF β facilitates the Vif-mediated degradation of APOBEC3 proteins.
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Extraction of Hemocytes from Drosophila melanogaster Larvae for Microbial Infection and Analysis
TL;DR: A method for definite reconciliation of pathogen invasion and confirmation of infection using bacterial and viral pathogen types and an efficient method for hemocyte extraction to obtain enough live hemocytes from Drosophila larvae for ex vivo and in vivo infection experiments are presented.
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Alpha Synuclein Inhibits Snare Mediated Vesicle Fusion
TL;DR: Investigating the mechanism by which αS modulates SNARE-mediated vesicle fusion finds that αS inhibits fusion in a manner that correlates with its affinity for the lipid bilayer, rather than SNARE components.
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