David Bosque
Rockefeller University
4 Papers
David Bosque is an academic researcher from Rockefeller University. The author has contributed to research in topics: Cytidine deaminase & Biology. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.
Davide F. Robbiani,Stephanie Deroubaix,Niklas Feldhahn,Thiago Y. Oliveira,Elsa Callen,Qiao Wang,Mila Jankovic,Israel Tojal da Silva,Philipp C. Rommel,David Bosque,Tom Eisenreich,André Nussenzweig,Michel C. Nussenzweig,Michel C. Nussenzweig +13 more
TL;DR: Although infection does not change the overall rate, it modifies lymphomagenesis to favor mature B cell lymphomas that are AID dependent and show chromosome translocations, and favors mature B Cell cancers by eliciting protracted AID expression in GC B cells.
171
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
Pierre Guermonprez,Julie Helft,Carla Claser,Stephanie Deroubaix,Henry Karanje,Anna Gazumyan,Guillaume Darasse-Jèze,Stephanie B. Telerman,Gaëlle Breton,Heidi A. Schreiber,Natalia Frias-Staheli,Eva Billerbeck,Marcus Dorner,Charles M. Rice,Alexander Ploss,Florian Klein,Melissa Swiecki,Marco Colonna,Alice O. Kamphorst,Matthew M. Meredith,Rachel E. Niec,Constantin N. Takacs,Fadi Mikhail,Aswin Hari,David Bosque,Tom Eisenreich,Tom Eisenreich,Miriam Merad,Yan Shi,Florent Ginhoux,Laurent Rénia,Britta C. Urban,Britta C. Urban,Michel C. Nussenzweig,Michel C. Nussenzweig +34 more
TL;DR: An innate sensing pathway triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand (Flt3l) release is described and found that type I IFN supports the upregulation of xanthine dehydrogenase.
160
Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.
Philipp C. Rommel,David Bosque,Alexander D. Gitlin,Gist F. Croft,Nathaniel Heintz,Nathaniel Heintz,Rafael Casellas,Michel C. Nussenzweig,Michel C. Nussenzweig,Skirmantas Kriaucionis,Skirmantas Kriaucionis,Davide F. Robbiani +11 more
TL;DR: It is discovered that AIDcre tags a small fraction of non-lymphoid cells starting at 10.5 days post conception (dpc), and that AIDsGFP+ cells are detectable at dpc 11.5 and 12.5.
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
Anne Bothmer,Davide F. Robbiani,Michela Di Virgilio,Samuel F. Bunting,Isaac A. Klein,Niklas Feldhahn,Jacqueline H. Barlow,Hua Tang Chen,David Bosque,Elsa Callen,André Nussenzweig,Michel C. Nussenzweig,Michel C. Nussenzweig +12 more
TL;DR: Analysis of 53BP1 mutants shows that chromatin association, oligomerization, and N-terminal ATM phosphorylation are all required for DNA end protection and joining as measured by immunoglobulin class switch recombination.