David A. Wacker
University of Minnesota
17 Papers
50 Citations
David A. Wacker is an academic researcher from University of Minnesota. The author has contributed to research in topics: Medicine & Chromatin. The author has an hindex of 5, co-authored 11 publications. Previous affiliations of David A. Wacker include University of Maryland, Baltimore & Yale University.
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Papers
Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes.
Brent D. Brower-Toland,David A. Wacker,Robert M. Fulbright,John T. Lis,W. Lee Kraus,Michelle D. Wang +5 more
TL;DR: The results suggest that the destabilizing effects of tail acetylation may be due to elimination of specific key interactions in the nucleosome.
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The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription.
David A. Wacker,Donald D. Ruhl,Ehsan H. Balagamwala,Kristine M. Hope,Tong Zhang,W. Lee Kraus +5 more
TL;DR: The catalytic domain of PARP-1, which does not bind nucleosomes on its own, cooperates with the DBD to promote chromatin compaction and efficient transcriptional repression in a manner independent of its enzymatic activity.
160
A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19
Michael A. Puskarich,Michael A. Puskarich,Nathan W. Cummins,Nicholas E. Ingraham,David A. Wacker,Ronald Reilkoff,Brian E. Driver,Michelle H. Biros,M. Fernanda Bellolio,Jeffrey G. Chipman,Andrew C. Nelson,Kenneth B. Beckman,Ryan A. Langlois,Tyler D. Bold,Matthew T. Aliota,Timothy W. Schacker,Helen Voelker,Thomas A. Murray,Joseph S. Koopmeiners,Christopher J. Tignanelli,Christopher J. Tignanelli +20 more
TL;DR: In this article, a multicenter blinded randomized clinical trial (RCT) was conducted to test the efficacy of losartan on outpatients with mild symptomatic COVID-19 disease, though assessment was limited by low event rate.
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REGULATION OF CHROMATIN STRUCTURE AND CHROMATIN-DEPENDENT TRANSCRIPTION BY POLY(ADP-RIBOSE) POLYMERASE-1 Possible targets for drug-based therapies
TL;DR: In this paper, the molecular and cellular aspects of PARP-1's chromatin-modulating activities, as well as the impact that these chromatin modulating activities have on the regulation of gene expression have been discussed.
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Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy*
David A. Wacker,Susan L Burton,John P. Berger,A. J. Hegg,J. Heisdorffer,Qi Wang,Emily J Medcraft,Ronald Reilkoff +7 more
TL;DR: Vitamin C monotherapy failed to significantly reduce mortality in septic shock patients as hypothesized and does not support its routine clinical use for this purpose.
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