David A. Scott
Sanford-Burnham Institute for Medical Research
17 Papers
1 Citations
David A. Scott is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Glutamine & Biology. The author has an hindex of 16, co-authored 17 publications.
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Papers
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
David A. Scott,Adam D. Richardson,Fabian V. Filipp,Christine A. Knutzen,Gary G. Chiang,Ze'ev Ronai,Andrei L. Osterman,Jeffrey W. Smith +7 more
TL;DR: This study provides a foundation for targeting metabolism for therapeutic benefit in melanoma by tracking metabolic flux using isotopically labeled nutrients and concludes that glutamine was a key nutrient providing a substantial anaplerotic contribution to the TCA cycle.
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Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Young Joo Jeon,Sihem Khelifa,Boris I. Ratnikov,David A. Scott,Yongmei Feng,Fabio Parisi,Chelsea Ruller,Eric Lau,Hyungsoo Kim,Laurence M. Brill,Tingting Jiang,David L. Rimm,Robert D. Cardiff,Gordon B. Mills,Jeffrey W. Smith,Andrei L. Osterman,Yuval Kluger,Ze'ev Ronai +17 more
TL;DR: Regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 by the ubiquitin ligase RNF5 underlies BCa response to chemotherapies and indicates positive prognosis in BCa.
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Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.
Edward L. LaGory,Colleen Wu,Cullen M. Taniguchi,Chien-Kuang Cornelia Ding,Jen-Tsan Chi,Rie von Eyben,David A. Scott,Adam D. Richardson,Amato J. Giaccia +8 more
TL;DR: It is demonstrated that PGC-1α, a central regulator of energy metabolism, is suppressed in VHL-deficient ccRCC by a HIF/Dec1-dependent mechanism and recapitulates key metabolic phenotypes ofccRCC and highlights the potential of targeting PGC -1α expression as a therapeutic modality for the treatment of ccR CC.
Functional Specialization in Proline Biosynthesis of Melanoma
Jessica De Ingeniis,Boris I. Ratnikov,Adam D. Richardson,David A. Scott,Pedro Aza-Blanc,Surya K. De,Marat D. Kazanov,Maurizio Pellecchia,Ze'ev Ronai,Andrei L. Osterman,Jeffrey W. Smith +10 more
TL;DR: The role of three isozymic versions of PYCR was addressed in human melanoma cells by tracking the fate of 13C-labeled precursors, providing the first clarification of the role of PyCRs to proline biosynthesis.
Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.
Fabian V. Filipp,Fabian V. Filipp,Boris I. Ratnikov,Jessica De Ingeniis,Jeffrey W. Smith,Andrei L. Osterman,David A. Scott +6 more
TL;DR: The historic notion that cancer is a disease of mitochondria is revised to show that glycolysis is decoupled from the tricarboxylic acid (TCA) cycle, and glutamine is used as an alternate carbon source.
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