David A. Dyment
Wellcome Trust
6 Papers
32 Citations
David A. Dyment is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Haplotype & Population. The author has an hindex of 4, co-authored 6 publications.
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Papers
Genetic susceptibility to MS: a second stage analysis in Canadian MS families
David A. Dyment,Cristen J. Willer,Beverly Scott,H. Armstrong,Arturs Ligers,Jan Hillert,Donald W. Paty,Stanley A. Hashimoto,Virginia Devonshire,John P. Hooge,Lorne F. Kastrukoff,Joel Oger,Luanne M. Metz,Sharon Warren,Walter Hader,Cristopher Power,Anthony Auty,Avindra Nath,R. F. Nelson,Mark S. Freedman,Donald G. Brunet,J E Paulseth,George P.A. Rice,Paul O'Connor,Pierre Duquette,Yves Lapierre,Gordon S. Francis,Jean-Pierre Bouchard,T. John Murray,Virender Bhan,Charles Maxner,William Pryse-Phillips,Mark Stefanelli,A. Dessa Sadovnick,Neil Risch,George C. Ebers +35 more
TL;DR: Future progress in the genetics of this complex trait may be helped by focussing on more ethnically homogeneous samples, using an increased number of MS families, and using transmission disequilibrium analysis in candidate regions rather than the affected relative pair linkage analysis.
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TCR beta polymorphisms and multiple sclerosis.
David A. Dyment,J L Steckley,K Morrison,Cristen J. Willer,M Z Cader,Gabriele C. DeLuca,A D Sadovnick,Neil Risch,G C Ebers +8 more
TL;DR: The results show no evidence for linkage and fail to establish an association between MS susceptibility and the TCR β locus.
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Short communication Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis
Sreeram V. Ramagopalan,Marko Cukjati,Gabriele C. DeLuca,David A. Dyment,Alexandra Degenhardt,A. Dessa Sadovnick,George C. Ebers +6 more
- 01 Jan 2008
TL;DR: In this article, the authors investigated whether mutations in the HFE gene influence the prognosis of the disease and found no evidence to suggest that mutations in HFE have any outcome modifying activity, although small effects cannot be ruled out.
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Short communication Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis
Sreeram V Ramagopalan,David A. Dyment,Blanca M. Herrera,Gabriele C. DeLuca,Matthew R. Lincoln,Sarah M. Orton,Lahiru Handunnetthi,Michael J. Chao,A. Dessa Sadovnick,George C. Ebers +9 more
- 01 Jan 2008
TL;DR: In this paper, the transmission of haplotypes of HLA-DRB1, DRB1-DQB1 and DRB-1-11 haplotypes was analyzed in 7093 individuals from 1432 MS families.
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