David A. Connor
Temple University
12 Papers
49 Citations
David A. Connor is an academic researcher from Temple University. The author has contributed to research in topics: Nicotine & Nicotinic agonist. The author has an hindex of 6, co-authored 12 publications. Previous affiliations of David A. Connor include University of Pennsylvania.
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Papers
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175
Liliana B. Menalled,Andrea E. Kudwa,Samuel I. Miller,Jon Fitzpatrick,Judy Watson-Johnson,Nicole Keating,Melinda C Ruiz,Richard Mushlin,William Alosio,Kristi McConnell,David A. Connor,Carol Murphy,Steve Oakeshott,Mei Kwan,Jose Beltran,Afshin Ghavami,Dani Brunner,Larry Park,Sylvie Ramboz,David Howland +19 more
TL;DR: A new mouse line, the zQ175 knock-in mouse, derived from a spontaneous expansion of the CAG copy number in the authors' CAG 140 knock- in colony is described, which carries a significantly higher CAG repeat length and is expected to be more significantly impaired than the parent line.
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Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.
Stephen Oakeshott,Fuat Balcı,Igor Filippov,Carol Murphy,Russell G. Port,David A. Connor,Ahmad Paintdakhi,Joseph LeSauter,Liliana B. Menalled,Sylvie Ramboz,Seung Kwak,David Howland,Rae Silver,Dani Brunner +13 more
TL;DR: The behavior of the BAC HD mouse model is studied using an 24/7 automated system, indicating significant lengthening of the circadian period in the mutant mice, indicating that circadian dysfunction is a core feature of HD.
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High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.
Fuat Balcı,Stephen Oakeshott,Jul Lea Shamy,Bassem F. El-Khodor,Igor Filippov,Richard Mushlin,Russell G. Port,David A. Connor,Ahmad Paintdakhi,Liliana B. Menalled,Sylvie Ramboz,David Howland,Seung Kwak,Dani Brunner +13 more
TL;DR: This work extends the prior demonstration that PhenoCube™ can characterize circadian dysfunction in BACHD mice and shows that this system is a sensitive and efficient tool for a first pass high-throughput screening of mouse disease models in general and mouse models of neurodegeneration in particular.
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The role of working memory and declarative memory in trace conditioning.
David A. Connor,Thomas J. Gould +1 more
TL;DR: The aim of this review is to integrate cognitive and neurobiological accounts of trace conditioning from preclinical and clinical studies to examine involvement of working and declarative memory.
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ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice.
TL;DR: Results suggest that modulation of hippocampal learning and memory using ABT-089 may be an effective component of novel therapeutic strategies for nicotine addiction.