Darshit Patel
2 Papers
Darshit Patel is an academic researcher. The author has contributed to research in topics: DNA gyrase & Topoisomerase IV. The author has an hindex of 2, co-authored 2 publications.
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Papers
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria
Colin K. Skepper,Duncan Armstrong,Carl J. Balibar,Douglas C. Bauer,Cornelia Bellamacina,Bret Benton,Dirksen E. Bussiere,Gianfranco De Pascale,Javier de Vicente,Charles R. Dean,Bhavesh Dhumale,L. Mark Fisher,John Fuller,Mangesh Fulsunder,Lauren M. Holder,Cheng Hu,Bhavin Kantariya,Guillaume Lapointe,Jennifer A. Leeds,Xiaolin Li,Peichao Lu,Anatoli Lvov,Sylvia Ma,Shravanthi Madhavan,Swapnil Malekar,David McKenney,Wosenu Mergo,Louis E. Metzger,Heinz E. Moser,Daniel Mutnick,Jonas Noeske,Colin Osborne,Ashish Patel,Darshit Patel,Tushar Patel,Krunal Prajapati,Katherine R Prosen,Folkert Reck,Daryl L. Richie,Alice Rico,Mark R. Sanderson,Shailesh Satasia,William S. Sawyer,Jogitha Selvarajah,Nirav Shah,Kartik Shanghavi,Wei Shu,Katherine V. Thompson,Martin Traebert,Anand Vala,Lakhan Vala,Dennis A. Veselkov,Jason Vo,Michael Wang,Marcella Widya,Sarah Williams,Yongjin Xu,Qin Yue,Richard Zang,Bo Zhou,Alexey Rivkin +60 more
TL;DR: The discovery and optimization of a series of 4-(aminomethyl)quinolin-2(1H)-ones, exemplified by 34, that inhibit bacterial DNA gyrase and topoisomerase IV and display potent activity against ciprofloxacin-resistant Gram-negative pathogens are described.
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Guillaume Lapointe,Colin K. Skepper,Lauren M. Holder,Duncan Armstrong,Cornelia Bellamacina,Johanne Blais,Dirksen E. Bussiere,Jianwei Bian,Cody Cepura,Helen Chan,Charles R. Dean,Gianfranco De Pascale,Bhavesh Dhumale,L. Mark Fisher,Mangesh Fulsunder,Bhavin Kantariya,Julie Kim,Sean King,Lauren Kossy,Upendra Kulkarni,Jay Parthiban Lakshman,Jennifer A. Leeds,Xiaolan Ling,Anatoli Lvov,Sylvia Ma,Swapnil Malekar,David McKenney,Wosenu Mergo,Louis E. Metzger,Keshav Mhaske,Heinz E. Moser,Mina Mostafavi,Sunil Namballa,Jonas Noeske,Colin Osborne,Ashish Patel,Darshit Patel,Tushar Patel,Philippe Piechon,Valery Polyakov,Krunal Prajapati,Katherine R Prosen,Folkert Reck,Daryl L. Richie,Mark R. Sanderson,Shailesh Satasia,Bhautik Savani,Jogitha Selvarajah,Vijay Sethuraman,Wei Shu,Kyuto Tashiro,Katherine V. Thompson,Krishniah Vaarla,Lakhan Vala,Dennis A. Veselkov,Jason Vo,Bhavesh Vora,Trixie Wagner,Laura Wedel,Sarah Williams,Satya Yendluri,Qin Yue,Aregahegn Yifru,Yong Zhang,Alexey Rivkin +64 more
TL;DR: In this paper, the authors describe the discovery and optimization of a novel series that inhibits bacterial DNA gyrase and topoisomerase IV via binding to, and stabilization of, DNA cleavage complexes.
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