Darrell Eacret
Children's Hospital of Philadelphia
14 Papers
2 Citations
Darrell Eacret is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Opioid & Medicine. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Darrell Eacret include University of Pennsylvania & Emory University.
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Papers
The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats.
Jiah Pearson-Leary,Chunyu Zhao,Kyle Bittinger,Darrell Eacret,Sandra Luz,Abigail Vigderman,Gabriel Dayanim,Seema Bhatnagar,Seema Bhatnagar +8 more
TL;DR: The results suggest the gut microbiome contributes to the depression-like behavior and inflammatory processes in the vHPC of stress vulnerable individuals.
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Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress.
Jiah Pearson-Leary,Darrell Eacret,R.J. Chen,Hajime Takano,B Nicholas,Seema Bhatnagar,Seema Bhatnagar +6 more
TL;DR: Vulnerability to stress is determined by a re-designed neurovascular unit characterized by increased neural activity, vascular remodeling and pro-inflammatory mechanisms in the vHPC, which suggests that dampening inflammatory processes by administering anti-inflammatory agents reduces vulnerability to stress.
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Reduced Orexin System Function Contributes to Resilience to Repeated Social Stress.
Laura A. Grafe,Darrell Eacret,Jane Dobkin,Seema Bhatnagar,Seema Bhatnagar +4 more
- 01 Mar 2018
TL;DR: Data suggest that lowering orexins promoted resilience to social defeat and may be an important target for treatment of stress-related disorders.
Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice
Jillybeth Burgado,Constance S. Harrell,Darrell Eacret,Renuka Reddy,Christopher J. Barnum,MariadeLourdes Tansey,Andrew H. Miller,Huichen Wang,Gretchen N. Neigh +8 more
TL;DR: Results indicate that 15 exposures to this innovative predatory stress paradigm are sufficient to elicit robust anxiety-like behaviors with evidence of co-morbid depressive-like behavior, as well as changes in cognitive behavior in male mice.
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Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress.
Laura A. Grafe,Darrell Eacret,Sandra Luz,Anthony L. Gotter,John J. Renger,Chris J. Winrow,Seema Bhatnagar,Seema Bhatnagar +7 more
TL;DR: Results indicate that the OX2R plays a role in acute stress, and can prevent habituation to repeated stress under conditions of high orexin release.
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