Darja Pollpeter
King's College London
10 Papers
122 Citations
Darja Pollpeter is an academic researcher from King's College London. The author has contributed to research in topics: Viral replication & Reverse transcriptase. The author has an hindex of 8, co-authored 10 publications.
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Papers
The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.
Tomas Doyle,Olivier Moncorgé,Boris Bonaventure,Darja Pollpeter,Marion Lussignol,Marine Tauziet,Luis Apolonia,Maria Teresa Catanese,Caroline Goujon,Michael H. Malim +9 more
TL;DR: NCOA7 provides a mechanism for immune regulation of endolysosomal physiology that not only suppresses viral entry into the cytosol from this compartment but may also regulate other V-ATPase-associated cellular processes, such as physiological adjustments to nutritional status, or the maturation and function of antigen-presenting cells.
ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor
Annie M. Bruns,Darja Pollpeter,Nastaran Hadizadeh,Sua Myong,John F. Marko,Curt M. Horvath,FromtheDepartmentsof ‡ MolecularBiosciencesand +6 more
- 01 Jan 2013
TL;DR: In this article, a single-molecule analysis of LGP2 and mutant vari- ants that dissociate basal from dsRNA-stimulated ATP hydrol- ysis was performed.
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Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection
Matthew D. J. Dicks,Caroline Goujon,Darja Pollpeter,Gilberto Betancor,Luis Apolonia,Julien R. C. Bergeron,Michael H. Malim +6 more
TL;DR: It is proposed that lower-order oligomerization of MX2 is sufficient for the effective inhibition of HIV-1, implying that fundamental differences exist between the antiviral mechanisms employed by these closely related proteins.
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Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.
TL;DR: This work extends published observations on SAMHD1 nuclear localization to a natural cell type for HIV-1 infection, identifies KPNA2/KPNB1 as cellular proteins important for SAM HD1 nuclear import, and indicates that components of the nuclear proteasomal degradation machinery are required forSAMHD1 degradation.
Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.
Torsten Schaller,Torsten Schaller,Torsten Schaller,Lorenzo Bulli,Lorenzo Bulli,Darja Pollpeter,Gilberto Betancor,Juliane Kutzner,Luis Apolonia,Nikolas Herold,Nikolas Herold,Robin Burk,Michael H. Malim +12 more
TL;DR: It is proposed here that the INM components SUN1 and SUN2, two members of the linker of nucleoskeleton and cytoskeleton (LINC) complex, may interact with incoming HIV-1 replication complexes and affect key steps of infection.
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