Darja Marolt
New York Stem Cell Foundation
26 Papers
90 Citations
Darja Marolt is an academic researcher from New York Stem Cell Foundation. The author has contributed to research in topics: Embryonic stem cell & Tissue engineering. The author has an hindex of 18, co-authored 26 publications. Previous affiliations of Darja Marolt include Columbia University & Massachusetts Institute of Technology.
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Papers
Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance.
Mirjam Fröhlich,Warren L. Grayson,Leo Q. Wan,Darja Marolt,Matej Drobnič,Gordana Vunjak-Novakovic +5 more
TL;DR: The biological guidelines for tissue engineering of bone, the bioreactor cultivation of human mesenchymal stem cells on three-dimensional scaffolds, and the need for vascularization and functional integration of bone grafts following implantation are discussed.
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Darja Marolt,Alexander Augst,Lisa E. Freed,Charu Vepari,Robert Fajardo,Nipun Patel,Martha L. Gray,Martha L. Gray,Martha L. Gray,Michelle Farley,Michelle Farley,Michelle Farley,David L. Kaplan,Gordana Vunjak-Novakovic,Gordana Vunjak-Novakovic +14 more
TL;DR: Whether large cartilaginous and bone-like tissue constructs can be selectively engineered using the same cell population, the same scaffold type and same hydrodynamic environment by varying the medium composition is tested.
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Potential pathophysiological mechanisms in osteonecrosis of the jaw
Regina Landesberg,Victoria L. Woo,Serge Cremers,Matthew Cozin,Darja Marolt,Gordana Vunjak-Novakovic,Stavroula Kousteni,Srikala Raghavan +7 more
TL;DR: Proposed mechanisms underlying ONJ development are explored and potential areas for future investigation are identified.
Optimizing the medium perfusion rate in bone tissue engineering bioreactors
Warren L. Grayson,Darja Marolt,Sarindr Bhumiratana,Mirjam Fröhlich,X. Edward Guo,Gordana Vunjak-Novakovic +5 more
TL;DR: The complexity of the cellular responses found at different flow velocities underscores the need to use a range of evaluation parameters to determine the quality of engineered bone.
154
Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells.
Ivan Marcos-Campos,Darja Marolt,Petros Petridis,Sarindr Bhumiratana,Daniel Schmidt,Gordana Vunjak-Novakovic +5 more
TL;DR: Bone mineral was beneficial for the higher expression of bone markers in cultured cells and more robust accumulation of the new bone matrix, and the effects of the matrix architecture and mineral content on bone formation by human embryonic stem cells (hESC).
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