Darcy E. Kahn
Anschutz Medical Campus
17 Papers
1 Citations
Darcy E. Kahn is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 7, co-authored 10 publications.
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Papers
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.
Leigh Perreault,Sean A. Newsom,Allison Strauss,Anna Kerege,Darcy E. Kahn,Kathleen A. Harrison,Janet K. Snell-Bergeon,Travis Nemkov,Angelo D'Alessandro,Matthew R. Jackman,Paul S. MacLean,Bryan C. Bergman +11 more
TL;DR: Subcellular localization of skeletal muscle DAGs and sphingolipids should be considered when developing therapeutic interventions to treat insulin resistance and suggest that whole-cell concentrations of lipids obscure meaningful differences in compartmentalization.
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans
Stephan Sachs,Simona Zarini,Darcy E. Kahn,Kathleen A. Harrison,Leigh Perreault,Tzu L. Phang,Sean A. Newsom,Allison Strauss,Anna Kerege,Jonathan A. Schoen,Daniel H. Bessesen,Thomas Schwarzmayr,Elisabeth Graf,Dominik Lutter,Jan Krumsiek,Susanna M. Hofmann,Bryan C. Bergman +16 more
TL;DR: Data show that factors secreted from IMAT modulate muscle insulin sensitivity, possibly via secretion of inflammatory cytokines and extracellular matrix proteins, and by increasing local FFA concentration in humans.
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Is regular exercise an effective strategy for weight loss maintenance
Rebecca M. Foright,David M. Presby,Vanessa D. Sherk,Darcy E. Kahn,L.A. Checkley,Erin D. Giles,Audrey Bergouignan,Janine A. Higgins,Matthew R. Jackman,James O. Hill,Paul S. MacLean +10 more
TL;DR: Critical questions remain including sex differences, individual variability and compensatory behaviors in response to exercise, exercise adherence, the role of energy flux and the molecular mechanisms mediating the beneficial effects of exercise after weight loss and during weight regain.
104
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Rani K. Powers,Rachel Culp-Hill,Michael P. Ludwig,Keith P Smith,Katherine A. Waugh,Ross Minter,Kathryn D. Tuttle,Hannah C Lewis,Angela L. Rachubinski,Ross E Granrath,Maria Carmona-Iragui,Rebecca B. Wilkerson,Darcy E. Kahn,Molishree Joshi,Alberto Lleó,Rafael Blesa,Juan Fortea,Angelo D'Alessandro,James C. Costello,Kelly D. Sullivan,Joaquín M. Espinosa +20 more
TL;DR: A large metabolomics study of plasma and cerebrospinal fluid shows in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively.
Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
Melanie Cree-Green,Bryan C. Bergman,Eda Cengiz,Larry A. Fox,Tamara S. Hannon,Kellee M. Miller,Brandon M. Nathan,Laura Pyle,Laura Pyle,Darcy E. Kahn,Michael Tansey,Eileen Tichy,Eva Tsalikian,Ingrid Libman,Kristen J. Nadeau +14 more
TL;DR: In this paper, a double-blind, placebo-controlled clinical trial was conducted to measure peripheral, hepatic, and adipose insulin sensitivity before and after metformin or placebo therapy in youth with obesity with type 1 diabetes.