Danxin Wang
University of Florida
8 Papers
6 Citations
Danxin Wang is an academic researcher from University of Florida. The author has contributed to research in topics: Gene & Messenger RNA. The author has an hindex of 2, co-authored 8 publications. Previous affiliations of Danxin Wang include The Ohio State University Wexner Medical Center & University of Texas Southwestern Medical Center.
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Papers
Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver
TL;DR: It is found that ESR1 serves as a key transcription factor function in regulating CYP3A4, the main drug metabolizing enzymes in liver, and it appears to be acting at least in part in a ligand-free fashion.
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Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms
Roshan Mascarenhas,Maciej Pietrzak,Ryan M. Smith,Amy Webb,Danxin Wang,Audrey C. Papp,Julia K. Pinsonneault,Michal Seweryn,Grzegorz A. Rempala,Wolfgang Sadee +9 more
TL;DR: Allele-selective polysome recruitment revealed strong genetic influence for multiple RNAs, attributable either to differential expression of RNA isoforms or to differential loading onto polysomes, the latter defining a direct genetic effect on translation.
Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients.
Di-na Chen,Huijie Lu,Weiguo Sui,Li-qing Li,Jian Xu,Tengfei Yang,Siyao Yang,Ping Zheng,Yan Chen,Jiejing Chen,Wen Xue,Qing-ping Li,Que Zheng,De-mei Ye,Wolfgang Sadee,Danxin Wang,Wanying Qian,Liusheng Lai,Chuan-jiang Li,Liang Li +19 more
TL;DR: Wang et al. as discussed by the authors analyzed the association between 58 single nucleotide polymorphisms (SNPs) across the CYP3A gene cluster and the log-transformed tacrolimus concentration/dose ratio (log (C0/D)) in 819 renal transplant recipients (Discovery cohort).
6
Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure
Jasmine A. Luzum,Jasmine A. Luzum,Christopher Ting,Edward L. Peterson,Hongsheng Gui,Tyler Shugg,L. Keoki Williams,Liang Li,Wolfgang Sadee,Danxin Wang,David E. Lanfear +10 more
TL;DR: A recently discovered cardiac-specific regulatory variant for PRKCA (rs9909004) was independently associated with a decreased risk for all-cause mortality in patients with HF and did not interact with mortality benefit associated with cornerstone HF pharmacotherapies.
2
Patent
Procédés de criblage d'antagonistes neutres et d'agonistes inverses des récepteurs opioïdes et leurs utilisations
Wolfgang Sadee,Danxin Wang +1 more
- 16 Dec 2008
TL;DR: In this article, the authors propose a method for procedes de criblage dantagonistes neutres et dagonistes inverses des recepteurs opioides and leurs utilisation.