Danny Scarponi
University of Regensburg
14 Papers
3 Citations
Danny Scarponi is an academic researcher from University of Regensburg. The author has contributed to research in topics: Abelian group & Medicine. The author has an hindex of 1, co-authored 5 publications.
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Papers
The impact of alternative delivery strategies for novel tuberculosis vaccines in low-income and middle-income countries: a modelling study
Rebecca A. Clark,Christinah Mukandavire,Allison Portnoy,Chathika K Weerasuriya,Arminder K Deol,Danny Scarponi,Andrew Iskauskas,Roel Bakker,Matthew Quaife,Shelly Malhotra,Nebiat Gebreselassie,Matteo Zignol,Raymond Hutubessy,Birgitte Giersing,Mark Jit,Rebecca Harris,Nicolas A Menzies,Richard G. White +17 more
TL;DR: Novel tuberculosis vaccines could have substantial impact, which will vary depending on delivery strategy, and Accelerated introduction similar to the pace of COVID-19 vaccines could approximately double the lives saved before 2050.
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New tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination
Rebecca A. Clark,Chathika K Weerasuriya,Allison Portnoy,Christinah Mukandavire,Matthew Quaife,Roel Bakker,Danny Scarponi,Rebecca Harris,Kirankumar Rade,Sanjay Mattoo,Dheeraj Tumu,Nicolas A Menzies,Richard G. White +12 more
TL;DR: M72/AS01_E and BCG-revaccination could be impactful and cost-effective in India but there is great uncertainty in impact, especially given the unknowns surrounding the mechanism of effect and infection status required for vaccine efficacy.
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Demonstrating multi-country calibration of a tuberculosis model using new history matching and emulation package - hmer
TL;DR: In this article , the authors developed a new, user-friendly R package hmer to simply and efficiently perform history matching with emulation, which has been successfully applied to such models, but has not been widely used in epidemiology partly due to the lack of available software.
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Is neglect of self-clearance biassing TB vaccine impact estimates?
Danny Scarponi
- 11 Apr 2023
TL;DR: In this article , the authors explored how the inclusion of self-clearance in models of tuberculosis affects the estimates of vaccine impact in China and India and found that self-cleared individuals had minimal impact on estimated reductions in incidence for vaccines that work regardless of infection status.
Modelling the health and economic impacts of M72/AS01E vaccination and BCG-revaccination: estimates for South Africa
T. Sumner,Rebecca A. Clark,Christinah Mukandavire,A. Portnoy,Chathika K Weerasuriya,R. Bakker,Danny Scarponi,M. Hatherill,N. A. Menzies,Richard G. White +9 more
TL;DR: The results show that M72/AS01E vaccination or BCG-revaccination could be cost-effective in South Africa, however, there is considerable uncertainty in the estimated impact and costs due to uncertainty in vaccine characteristics and the choice of delivery strategy.
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