Danny R. Gray
University of North Carolina at Chapel Hill
7 Papers
181 Citations
Danny R. Gray is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Prostate & Prostate cancer. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Danny R. Gray include Harvard University & Beth Israel Deaconess Medical Center.
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Papers
Origin of Androgen-Insensitive Poorly Differentiated Tumors in the Transgenic Adenocarcinoma of Mouse Prostate Model
Wendy J. Huss,Danny R. Gray,Keyvan Tavakoli,Meghan E. Marmillion,Lori E. Durham,Mac Johnson,Norman M. Greenberg,Gary J. Smith,Gary J. Smith +8 more
TL;DR: The foci of neuroendocrine-like cells that express SV40-Tag and synaptophysin, but lack AR, arise independent of androgen-deprivation and represent the source of the poorly differentiated tumors that are the lethal phenotype in the TRAMP model.
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Androgen deprivation induces rapid involution and recovery of human prostate vasculature
Alejandro Godoy,Viviana P. Montecinos,Danny R. Gray,Paula Sotomayor,Jeffrey M. Yau,R. Robert Vethanayagam,Swaroop S. Singh,James L. Mohler,James L. Mohler,Gary J. Smith +9 more
TL;DR: Primary xenografts of human benign and CaP tissue transplanted to immunocompromized SCID mice were used to characterize the response of the prostate vasculature to androgen deprivation, and VEGF-A expression by prostate endothelial cells appears to represent a key facilitator of the vascular rebound in human prostate tissue induced by removal of circulating testicular androgens.
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Short-Term Human Prostate Primary Xenografts An in Vivo Model of Human Prostate Cancer Vasculature and Angiogenesis
Danny R. Gray,Wendy J. Huss,Jeffrey M. Yau,Lori E. Durham,Eric S. Werdin,William K. Funkhouser,Gary J. Smith +6 more
TL;DR: It is reported that primary xenografts of human CaP and of noninvolved areas of the human prostate peripheral zone transplanted to athymic nude mice provide a unique model of human angiogenesis occurring in an intact human prostate tissue microenvironment and for comparison ofAngiogenesis in CaP versus benign prostate.
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Evidence of pluripotent human prostate stem cells in a human prostate primary xenograft model.
TL;DR: The phenotypic plasticity of the human prostate stem cell within human prostate tissue was examined to determine the response of the stem cell to changes in the androgenic environment.
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Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use.
TL;DR: Immunoassays for pentamidine would have many advantages over the HPLC methods including relative simplicity of assay format and required equipment, convenience in sample preparation and reduction in time and cost of assays.
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