Danlan Wei
National Institutes of Health
20 Papers
4 Citations
Danlan Wei is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Homing (hematopoietic) & Biology. The author has an hindex of 7, co-authored 11 publications.
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Papers
The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
Claudia Cicala,Elena Martinelli,Jonathan P. McNally,Diana J. Goode,Ravindra Gopaul,Joseph Hiatt,Katija Jelicic,Shyamasundaran Kottilil,Katilyn Macleod,Angeline O'Shea,Nikita Patel,Donald Van Ryk,Danlan Wei,Massimiliano Pascuccio,Ling Yi,Lyle R. McKinnon,Preson Izulla,Joshua Kimani,Rupert Kaul,Anthony S. Fauci,James Arthos +20 more
TL;DR: The specific affinity of gp120 for α4β7 provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.
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The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission
Fatima Nawaz,Claudia Cicala,Donald Van Ryk,Katharine E. Block,Katija Jelicic,Jonathan P. McNally,Olajumoke Ogundare,Massimiliano Pascuccio,Nikita Patel,Danlan Wei,Anthony S. Fauci,James Arthos +11 more
TL;DR: The results suggest that the genetic bottleneck that occurs after transmission may frequently involve a relative requirement for the productive infection of α4β7 +/CD4+ T cells.
Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.
Jason Yolitz,Catherine Schwing,Julia Chang,Donald Van Ryk,Fatima Nawaz,Danlan Wei,Claudia Cicala,James Arthos,Anthony S. Fauci +8 more
TL;DR: It is shown that the signal peptide (SP) of HIV Env can impact the glycan profile of gp120, which in turn impacts antigenicity of the mature protein, indicating that the SP is likely subject to antibody-mediated immune pressure.
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MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells
Sinmanus Vimonpatranon,Lívia R. Góes,Amanda Chan,Isabella Licavoli,Jordan McMurry,Samuel R Wertz,Anush Arakelyan,Dawei Huang,Andrew Jiang,Cindy Huang,Joyce Zhou,Jason Yolitz,Alexandre Girard,Donald Van Ryk,Danlan Wei,Il-Young Hwang,Craig Martens,Kishore Kanakabandi,Kimmo Virtaneva,Stacy M. Ricklefs,Benjamin Darwitz,Marcelo A. Soares,Kovit Pattanapanyasat,Anthony S. Fauci,James Arthos,Claudia Cicala +25 more
TL;DR: In this article , costimulation via MAdCAM-1 and retinoic acid (RA), two constituents of gut tissues, together with TGF-β, promote the differentiation of CD4+ T cells into a distinct subset α4β7+CD69+CD103+ TRM-like cells.
Identification of CD38, CD97, and CD278 on the HIV surface using a novel flow virometry screening assay
J. Burnie,Claire Fernandes,Deepa Chaphekar,Danlan Wei,Shubeen Ahmed,Arvin Tejnarine Persaud,Nawrah Khader,Claudia Cicala,James Arthos,Vera A. Tang,Christina Guzzo +10 more
TL;DR: A novel flow virometry assay identifies 59 new proteins on HIV virions, including CD38, CD97, and CD278, which are consistently present across diverse HIV isolates, providing new insights into virus biology and demonstrating the assay's utility for high-throughput single-virion phenotyping.
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