A tridentate ligand N–(2–hydroxybenzylidene)pyridine–2–amine has been prepared by condensation of salicylaldehyde and  2–aminopyridine in absolute ethanol. M(II) complexes (M= Mn and Ni) of the ligand were also prepared, recovered by filtration and purified by recrystallization in absolute methanol. Characterization of the prepared compounds was done on the basis of FTIR spectroscopy, solubility test, melting  point/decomposition temperature, conductivity and magnetic susceptibility measurements. Job’s method of continuous variation was used to determine the number of ligands coordinated to the metal ions. The result indicated 1:2 Metal (II) to ligand ratio in both the complexes. Appearance of a sharp peak at 1596cm-1 in the FTIR spectra of the ligand indicated the formation of the azomethine (-C=N-) bond. This peak shifted to lower frequencies (1590 cm-1 and 1557 cm-1) in the spectra of the Mn2+ and Ni2+ complexes respectively due to coordination of the azomethine nitrogen to the metal ions. Antimicrobial activities of the ligand and the complexes were studied on Staphylococcus aureus,  Escherichia coli, Klebsiella pneumonia, Aspergillus funigathus and Mucor sp . isolates using disc diffusion method. The results obtained indicated that the test compounds are active against most of the tested isolates. Antioxidant activity of the compounds was tested using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging method. The lower IC50 value (2.27 μg/ml) obtained in the ligand, by probit analysis using SPSS 16.0, indicates its high antioxidant property. Keywords : Salicylaldehyde, Azomethine, Reflux, Antimicrobial and Antioxidant.

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In vitro antimicrobial and antioxidant studies on N-(2- hydroxylbenzylidene) pyridine -2-amine and its M(II) complexes

Reaction of ethanolic solutions of 2-aminobenzoic acid and 2-thiophenecarboxyldehyde gave a Schiff base. The reaction of the ethanolic solutions of the Schiff base with metal (II) chlorides formed complex compounds. Their solubility, melting point/decomposition temperature, molar conductance, and IR were carried out. The melting point of the Schiff base and the decomposition temperature of the complexes determined are high. The Schiff base and its metal complexes are soluble in common organic solvent but insoluble in water. The molar conductance of the complexes determined suggested that the complex compounds are non-electrolytes. The empirical formula calculation of the complex compounds indicated the formula [ML 2 ].H 2 O. The infrared spectral data of the Schiff base and its metal complexes showed bands at 1600 cm -1 and 1610 cm -1 , which are assigned to v(C=N) stretching frequencies. The bands at 500 – 515 cm -1 and 490 – 495 cm -1 are attributable to v(M-O) and v(M-N) stretching vibrations. The spectral bands in the range 3092 – 3298 cm-1 are assigned to v(O-H) stretching frequencies. The dissociation constant of the Schiff base is 6.8, indicating a weak acid. The stability constants of the complexes are high

Spectral and potentiometric Studies on Manganese (II) and Cobalt (II) Complexes With Schiff Base Derived from 2-thiophenecarboxylaldehyde and 2-Aminobenzoic Acid

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Spectral and potentiometric Studies on Manganese (II) and Cobalt (II) Complexes With Schiff Base Derived from 2-thiophenecarboxylaldehyde and 2-Aminobenzoic Acid