Danilo Ritz
University of Duisburg-Essen
13 Papers
2 Citations
Danilo Ritz is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Danilo Ritz include ETH Zurich.
Chat about Author
Papers
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
TL;DR: Identification of the pathway by which caveolin-1 is degraded when caveolae assembly is compromised suggests that “caveosomes” may be endosomal accumulations of the protein awaiting degradation.
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
Mayura Meerang,Danilo Ritz,Danilo Ritz,Shreya Paliwal,Zuzana Garajova,Matthias Bosshard,Niels Mailand,Pavel Janscak,Ulrich Hübscher,Hemmo Meyer,Hemmo Meyer,Kristijan Ramadan +11 more
TL;DR: Findings identify the p97–UFD1–NPL4 complex as an essential factor in ubiquitin-governed DNA-damage response, highlighting its importance in guarding genome stability.
271
TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
TL;DR: It is shown that upon inhibition of TORC1 by rapamycin or nitrogen starvation, Stm1 (suppressor of target of Myb protein 1) forms non-translating, dormant 80S ribosomes, which regulate ribosomal dormancy in an evolutionarily conserved manner via a ribosome preservation factor.
Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis
Irina C. Frei,Diana Weissenberger,Danilo Ritz,Wolf Heusermann,Marco Colombi,Mitsugu Shimobayashi,Michael N. Hall +6 more
TL;DR: In this article , the authors identified a network of calcitonin gene-related protein (CGRP)-positive sensory neurons in murine white adipose tissue (WAT) and found that adipose mammalian target of rapamycin complex 2 (mTORC2) is required for arborization of sensory neurons, but not of sympathetic neurons.
14
Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α.
Laura M. de Smalen,Anastasiya Börsch,Aurel B. Leuchtmann,Jonathan F. Gill,Danilo Ritz,Mihaela Zavolan,Christoph Handschin +6 more
TL;DR: Targeted elevation of PGC-1α, as well as induction in the context of exercise, rectify mitochondrial protein synthesis and, moreover, improve protein quality control in skeletal muscle, providing a mechanistic connection between proteostasis and mitochondrial function in physiological and pathological muscle aging.
11