Danielle Sequeira
6 Papers
Danielle Sequeira is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases.
Tze How Mok,Akin Nihat,Connie Luk,Danielle Sequeira,Mark Batchelor,Simon Mead,John Collinge,Graham S. Jackson +7 more
TL;DR: It is demonstrated for the first time that BV rPrP is susceptible to conversion by human CSF samples containing certain prion strains not previously responsive in conventional rPrPs, thus justifying further optimisation for wider diagnostic and prognostic use.
Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease
Tze How Mok,Akin Nihat,Nour K. Majbour,Danielle Sequeira,Leah Holm-Mercer,Thomas Coysh,Lee Darwent,Mark James Batchelor,Bradley R. Groveman,Christina D. Orrú,Andrew G. Hughson,Amanda Heslegrave,Rhiannon Laban,E. Veleva,Ross W. Paterson,Ashvini Keshavan,Jonathan M. Schott,Imogen Swift,Carolin Heller,Jonathan D. Rohrer,Alexander Gerhard,Christopher C Butler,James B. Rowe,Mario Masellis,Miles D. Chapman,Michael P. Lunn,Jan Bieschke,P. S. Jackson,Henrik Zetterberg,Byron Caughey,Peter Rudge,John Collinge,Simon Mead +32 more
TL;DR: In this article , the authors report the accrual of a longitudinal biofluid resource in patients, controls and healthy people at risk of prion diseases, to which ultrasensitive techniques such as real-time quaking-induced conversion (RT-QuIC) and single molecule array (Simoa) digital immunoassays were applied for preclinical biomarker discovery.
Prevalence and Treatments of Movement Disorders in Prion Diseases: A Longitudinal Cohort Study
TL;DR: Prion diseases cause a range of movement disorders involving the cortical, extrapyramidal, and cerebellar systems, and yet there are no large systematic studies of their prevalence, features, associations, and responses to commonly used treatments.
Trajectories of neurodegeneration and seed amplification biomarkers prior to disease onset in individuals at risk of prion disease
Tze How Mok,Akin Nihat,Nour K. Majbour,Danielle Sequeira,Leah Holm-Mercer,Thomas Coysh,Lee Darwent,Matthew Batchelor,Bradley R. Groveman,Cd Orrù,A. Hughson,Amanda Heslegrave,R. Laban,E. Veleva,Ross W. Paterson,Ashvini Keshavan,Jon M. Schott,Imogen Swift,Carolin Heller,J. Rohrer,Alexander Gerhard,Christopher C Butler,J. Rowe,Mario Masellis,Miles D. Chapman,Margaret C. Lunn,Jan Bieschke,P. S. Jackson,Henrik Zetterberg,Byron Caughey,Peter Rudge,John Collinge,Simon Mead +32 more
TL;DR: In this article , the authors report the accrual of a longitudinal biofluid resource in patients, controls and healthy people at-risk of prion diseases, to which ultrasensitive techniques such as real-time quaking-induced conversion (RT-QuIC), and single molecule array (Simoa) digital immunoassays were applied for preclinical biomarker discovery.
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Inherited prion disease caused by a novel frameshift mutation of PRNP resulting in protein truncation at codon 157.
Leah Holm-Mercer,Tze How Mok,Danielle Sequeira,Thomas Coysh,Peter Rudge,H. Ramadan,Lee Darwent,Tracy Campbell,Thomas P. Murphy,Colin Smith,Diane Ritchie,Sebastian Brandner,Zane Jaunmuktane,John Collinge,Simon Mead +14 more