Danielle Lenig
Basel Institute for Immunology
6 Papers
37 Citations
Danielle Lenig is an academic researcher from Basel Institute for Immunology. The author has contributed to research in topics: CC chemokine receptors & CCL21. The author has an hindex of 6, co-authored 6 publications.
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Papers
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
TL;DR: It is demonstrated that chemokine receptors are markers of naive and polarized T cell subsets and suggested that flexible programs of chemokin receptor gene expression may control tissue-specific migration of effector T cells.
1.6K
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
Federica Sallusto,Patrick Schaerli,Pius Loetscher,Christoph Schaniel,Danielle Lenig,Charles R. Mackay,Shixin Qin,Antonio Lanzavecchia +7 more
TL;DR: Different patterns of chemokine receptors in immature and mature DC are consistent with “inflammatory” and “primary response” phases of DC function.
1.3K
Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy
TL;DR: Observations show that IL-2 expression is controlled at the translational level, by differential ribosome loading, and suggest that translational control ofIL-2 mRNA may be a molecular mechanism by which anergy is attained.
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Distinct patterns and kinetics of chemokine production regulate dendritic cell function.
Federica Sallusto,Belinda Palermo,Danielle Lenig,Minja Miettinen,Sampsa Matikainen,Ilkka Julkunen,Reinhold Förster,Ralf Burgstahler,Martin Lipp,Antonio Lanzavecchia +9 more
TL;DR: While CCR1 and CCR5 were down‐regulated by endogenous or exogenous chemokines, CCR7 levels gradually increased in maturing DC and showed a striking resistance to ligand‐induced down‐regulation, explaining how DC can sustain the response to SLC and ELC throughout the maturation process.