Danielle John
University of Leeds
4 Papers
87 Citations
Danielle John is an academic researcher from University of Leeds. The author has contributed to research in topics: Cholinergic neuron & Cholinergic. The author has an hindex of 4, co-authored 4 publications.
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Papers
Membrane targeting, shedding and protein interactions of brain acetylcholinesterase.
David A. Hicks,Danielle John,Natalia Z. Makova,Zaineb Henderson,Natalia N. Nalivaeva,Natalia N. Nalivaeva,Anthony J. Turner +6 more
TL;DR: In this article, the authors present a review of cholinesterase membrane localization in brain and propose mechanisms for its lipid domain targeting, secretion and protein-protein interactions, and whether this process and its apparent association with α7 nicotinic acetylcholine receptors and metabolism of Alzheimer's amyloid precursor protein is determined by its association with lipid raft domains either in normal or pathological situations.
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Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
TL;DR: The results suggest the presence of functional somato-dendritic α7⁎nicotinic receptors on immature granule cells of the postnatal dentate gyrus, consistent with studies implicating α7€nicotinics receptors in dendritic maturation of dentates gyrus neurons in adult brain.
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Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: an immunocytochemical study.
TL;DR: Investigations showed that PRiMA immunoreactivity is associated with the membranes of the somata, dendrites and axons of cholinergic neurons in the basal forebrain, striatum and pedunculopontine nuclei, i.e. the neurons that innervate forebrain and brainstem structures.
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Effects of geroprotective peptides on the activity of cholinesterases and formation of the soluble form of the amyloid precursor protein in human neuroblastoma SH-SY5Y cells
Natalia N. Nalivaeva,Natalia Z. Makova,E. G. Kochkina,Danielle John,V. A. Arutyunov,L. S. Kozina,A. V. Arutjunyan,Igor A. Zhuravin +7 more
TL;DR: The data obtained suggest that vilon and Epithalon have selective anticholinesterase properties and that epithalon can also stimulate APP cleavage and increase production of its soluble neuroprotective form.
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