Danielle Frost
Translational Genomics Research Institute
3 Papers
Danielle Frost is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 3, co-authored 3 publications.
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Papers
Association of CR1, CLU, and PICALM with Alzheimer’s disease in a cohort of clinically characterized and neuropathologically verified individuals
Jason J. Corneveaux,Amanda J. Myers,April N. Allen,Jeremy J. Pruzin,Manuel Ramirez,Anzhelika Engel,Mike A. Nalls,Kewei Chen,Wendy Lee,Kendria Chewning,Stephen Villa,Hunsar B. Meechoovet,Jill D. Gerber,Danielle Frost,Hollie Benson,Sean O'Reilly,Lori B. Chibnik,Joshua M. Shulman,Andrew B. Singleton,David Craig,Kendall Van Keuren-Jensen,Travis Dunckley,David A. Bennett,Philip L. De Jager,Christopher B. Heward,John Hardy,Eric M. Reiman,Matthew J. Huentelman +27 more
TL;DR: Assessment of the most replicated genetic associations for Alzheimer's disease using data generated on Affymetrix SNP 6.0 arrays confirms the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs.
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High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation
David O. Azorsa,RiLee H. Robeson,Danielle Frost,Bessie Meec hoovet,Gillian R. Brautigam,Chad A. Dickey,Chad A. Dickey,Christian Beaudry,Gargi D. Basu,David R Holz,Joseph A Hernandez,Kristen M. Bisanz,Leslie Gwinn,Andrew Grover,Joseph G. Rogers,Eric M. Reiman,Eric M. Reiman,Mike Hutton,Mike Hutton,Dietrich A. Stephan,Spyro Mousses,Travis Dunckley +21 more
TL;DR: These findings identify novel kinases that phosphorylate tau protein and provide a valuable reference data set describing the kinases involved in phosphorylating tau at an AD-relevant epitope.
β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites
Danielle Frost,Bessie Meechoovet,Tong Wang,Stephen T. Gately,Marco Giorgetti,Irina V. Shcherbakova,Travis Dunckley +6 more
TL;DR: Test the ability of harmine, and numerous additional β-carboline compounds, to inhibit the DYRK1A dependent phosphorylation of tau protein on serine 396, serine 262/serine 356 (12E8 epitope), and threonine 231 in cell culture assays and in vitroosphorylation assays.