Danielle Fallin
University of South Florida
11 Papers
107 Citations
Danielle Fallin is an academic researcher from University of South Florida. The author has contributed to research in topics: Apolipoprotein E & Allele. The author has an hindex of 9, co-authored 11 publications.
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Papers
No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples
Fiona Crawford,Melissa J. Freeman,Terrence Town,Danielle Fallin,Michael Gold,Ranjan Duara,Michael Mullan +6 more
TL;DR: Analysis of allelic frequencies of polymorphisms in the Tau gene for a possible allelic distortion in Alzheimer's cases demonstrated no interaction between either of these polymorphisms and APOE in conferring risk for AD, and haplotype analysis across both sites revealed no difference in haplotype frequencies between cases and controls.
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Familial and population-based studies of apolipoprotein E and Alzheimer's disease.
Michael Mullan,Paul Scibelli,Ranjan Duara,Danielle Fallin,Michael Gold,John A. Schinka,Jonathan Hoyne,Aaron Osborne,Steven Sevush,Fiona Crawford +9 more
TL;DR: It is concluded that any selection procedure tending to enrich samples for positive family history will also tend to artificially increase APOE epsilon 4 allele frequencies in probands, which is of significance in samples drawn from clinical settings where referral may be influenced by previous known family history.
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No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease
Danielle Fallin,Sarah A. J. Reading,John A. Schinka,Jonathan Hoyne,Paul Scibelli,Michael Gold,Fiona Crawford,Michael Mullan +7 more
TL;DR: By this analysis, ACT genotyping does not provide additional information about an individual's risk of Alzheimer's disease beyond the risk information conferred by APOE genotype alone, and Logistic regression analysis excludes ACT or the interaction between ACT and APOE as significant contributors in the prediction of disease status.
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APOE is linked to Alzheimer's disease in a large pedigree.
Xingang Cai,Danielle Fallin,Judith Stanton,Paul Scibelli,Ranjan Duara,Fiona Crawford,Michael Mullan +6 more
TL;DR: Given the wealth of evidence for association, but not linkage, of APOE4 to AD, it is believed that another factor (or factors) interact(s) with APOE to precipitate early disease, and produce positive linkage results.
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