Daniela Wetzel
University of Göttingen
7 Papers
Daniela Wetzel is an academic researcher from University of Göttingen. The author has contributed to research in topics: Clostridium difficile & Chromosomal translocation. The author has an hindex of 3, co-authored 3 publications.
Chat about Author
Papers
Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile.
Uwe Groß,Elzbieta Brzuszkiewicz,Katrin Gunka,Jessica Starke,Thomas Riedel,Boyke Bunk,Cathrin Spröer,Daniela Wetzel,Anja Poehlein,Cynthia Maria Chibani,Wolfgang Bohne,Jörg Overmann,Ortrud Zimmermann,Rolf Daniel,Heiko Liesegang +14 more
TL;DR: Findings show that evolutionary events based on horizontal gene transfer occur within an ongoing CDI and contribute to the adaptation of the species by the introduction of new genes into the genomes.
High prevalence of nontoxigenic Clostridium difficile isolated from hospitalized and non-hospitalized individuals in rural Ghana.
Iryna Janssen,Paul Cooper,Katrin Gunka,Maja Rupnik,Daniela Wetzel,Ortrud Zimmermann,Uwe Groß +6 more
TL;DR: The data suggest that C. difficile is currently not a major cause of diarrhoea in this setting, and the epidemiology and risk factors in a cross-sectional study in Eikwe, a rural community in Ghana awaits further investigation.
30
Deciphering mechanisms and implications of bacterial translocation in human health and disease.
TL;DR: In this article , the authors discuss current evidence for the detection of bacterial translocation, examine different translocation axes with a primary focus on the oral-gut axis, and outline currently known translocation mechanisms and how they adversely affect the host in disease.
23
High metabolic versatility of different toxigenic and non-toxigenic Clostridioides difficile isolates.
Thomas Riedel,Daniela Wetzel,Julia Danielle Hofmann,Simon Paul Erich Otto Plorin,Henning Dannheim,Mareike Berges,Ortrud Zimmermann,Boyke Bunk,Isabel Schober,Cathrin Spröer,Heiko Liesegang,Dieter Jahn,Jörg Overmann,Uwe Groß,Meina Neumann-Schaal,Meina Neumann-Schaal +15 more
TL;DR: In this paper, the authors characterized the growth behavior, motility and fermentation product formation of 17 different C difficile isolates comprising five different major genomic clades and five different toxin inventories in relation to the model strains 630Δerm and R20291 within 33 determined fermentation products, they identified two yet undescribed products (5-methylhexanoate and 4-(methylthio)-butanoate) of C Difficile.
The pH-responsive SmrR-SmrT system modulates C. difficile antimicrobial resistance, spore formation, and toxin production
Daniela Wetzel,Zavier A. Carter,Marcos P. Monteiro,Adrianne N. Edwards,Shonna M. McBride +4 more
TL;DR: The results indicate that SmrR represses smrT expression, while production of SmrT increases spore and toxin production, as well as resistance to antibiotics.