Daniela Roedl
Technische Universität München
5 Papers
33 Citations
Daniela Roedl is an academic researcher from Technische Universität München. The author has contributed to research in topics: Adult stem cell & LEKTI. The author has an hindex of 4, co-authored 5 publications.
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Papers
Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts
TL;DR: Progerin induces changes in the composition of the HGPS nuclear proteome, including alterations to several components of the protein degradation pathways, and sulforaphane (SFN), an antioxidant derived from cruciferous vegetables, stimulates proteasome activity and autophagy in normal and HGPS fibroblast cultures and reverses the phenotypic changes that are the hallmarks of HGPS.
Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo
Vera Wenzel,Daniela Roedl,Diana Gabriel,Leslie B. Gordon,Meenhard Herlyn,Reinhard Schneider,Johannes Ring,Karima Djabali +7 more
TL;DR: This study reports the isolation of naïve multipotent skin-derived precursor (SKP) cells from dermal fibroblast cultures from HGPS donors, and implies that this protein could induce stem cells exhaustion as a mechanism contributing to aging.
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rAAV2-mediated restoration of LEKTI in LEKTI-deficient cells from Netherton patients.
TL;DR: The results provide first evidence that gene transfer of SPINK5 results in increased LEKTI activity in NS-keratinocytes, thus offering a rational to further pursue such a gene therapy approach for NS.
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Naïve adult stem cells isolation from primary human fibroblast cultures.
TL;DR: A protocol for rapid isolation of adult stem cells from primary fibroblast cultures that are readily available from tissue banks around the world is established, opening new opportunities to dissect the molecular mechanisms underlying rare genetic diseases as well as modeling diseases in a dish.
Serine protease inhibitor lymphoepithelial Kazal type‐related inhibitor tends to be decreased in atopic dermatitis
TL;DR: The role of LEKTI in AD is assessed at an expressional and functional level and an association between genetic polymorphisms of SPINK5 and atopic diseases revealed contradictory results.