Daniela Pizzirani
University of Bologna
19 Papers
199 Citations
Daniela Pizzirani is an academic researcher from University of Bologna. The author has contributed to research in topics: Chemistry & Biological activity. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Daniela Pizzirani include Howard Hughes Medical Institute & Harvard University.
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Papers
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
Marinella Roberti,Daniela Pizzirani,Daniele Simoni,Riccardo Rondanin,Riccardo Baruchello,Caterina Bonora,Filippo Buscemi,Stefania Grimaudo,Manlio Tolomeo +8 more
TL;DR: Data indicate unambiguously that structural alteration of the stilbene motif of resveratrol can be extremely effective in producing potent apoptosis-inducing agents.
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Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells
Manlio Tolomeo,Stefania Grimaudo,Antonietta Di Cristina,Marinella Roberti,Daniela Pizzirani,Maria Meli,Luisa Dusonchet,Nicola Gebbia,Vincenzo Abbadessa,Lucia Crosta,Riccardo Barucchello,Giuseppina Grisolia,Francesco Paolo Invidiata,Daniele Simoni +13 more
TL;DR: The data show that pterostilbene and particularly 3,5-hydroxypterostILbene are interesting antitumor natural compounds that may be useful in the treatment of resistant hematological malignancies, including imatinib, non-responsive neoplasms.
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Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Marinella Roberti,Daniela Pizzirani,Maurizio Recanatini,Daniele Simoni,Stefania Grimaudo,Antonietta Di Cristina,Vincenzo Abbadessa,Nicola Gebbia,Manlio Tolomeo +8 more
TL;DR: The synthesis of a series of 3,5-dimethoxy analogues in which a variety of substituents were introduced at positions 2', 3', 4', and 5' of the stilbene scaffold showed a more potent apoptotic and differentiating activity and was active on both multidrug resistance and Bcr-Abl-expressing cells that were resistant to resveratrol.
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Nitrogen-containing heterocyclic quinones: a class of potential selective antitumor agents.
TL;DR: A summary of the most interesting heterocyclic quinones is given together with their biological property and studies concerning the importance of some structural features will be described.
80
Designing Soluble PROTACs: Strategies and Preliminary Guidelines
Diego Garcia Jimenez,Matteo Rossi Sebastiano,Maura Vallaro,V. Mileo,Daniela Pizzirani,Elisa Moretti,Giuseppe Ermondi,Giulia Caron +7 more
TL;DR: In this article , the thermodynamic solubilities (log S) of 21 commercial PROTACs were measured and the authors provided promising guidelines for optimizing PROTAC solubility in early drug discovery programs.
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