Daniela Passeri
Intercept Pharmaceuticals
17 Papers
77 Citations
Daniela Passeri is an academic researcher from Intercept Pharmaceuticals. The author has contributed to research in topics: Farnesoid X receptor & Bile acid. The author has an hindex of 11, co-authored 17 publications.
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Papers
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity
Sébastien Moniot,Mariantonietta Forgione,Mariantonietta Forgione,Alessia Lucidi,Gebremedhin Solomon Hailu,Angela Nebbioso,Vincenzo Carafa,Francesca Baratta,Lucia Altucci,Nicola Giacchè,Daniela Passeri,Roberto Pellicciari,Antonello Mai,Clemens Steegborn,Dante Rotili +14 more
TL;DR: A series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold are reported, providing novel Sirt 2 inhibitors with a compact scaffold and structural insights for further inhibitor improvement.
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Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
Maura Marinozzi,Andrea Carotti,Emanuele Sansone,Antonio Macchiarulo,Emiliano Rosatelli,Roccaldo Sardella,Benedetto Natalini,Giovanni Rizzo,Luciano Adorini,Daniela Passeri,Francesca De Franco,Mark Pruzanski,Roberto Pellicciari +12 more
TL;DR: A virtual screening procedure was applied to the discovery of structurally diverse non-steroidal Farnesoid X Receptor (FXR) agonists, and 1H-Pyrazole[3,4-e][1,4]thiazepin-7-one-based hit compound 7 was chosen for hit-to-lead optimization.
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Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: Role of the chirality on the biological activity
Maura Marinozzi,Andrea Carotti,Roccaldo Sardella,Federica Buonerba,Federica Ianni,Benedetto Natalini,Daniela Passeri,Giovanni Rizzo,Roberto Pellicciari +8 more
TL;DR: A deep investigation of the different putative binding modes adopted by these enantiomerically pure ligands using computational modeling studies confirmed the enantioselectivity of FXR towards this class of molecules.
17
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification.
Serena Mostarda,Daniela Passeri,Andrea Carotti,Bruno Cerra,Carolina Colliva,Tiziana Benicchi,Antonio Macchiarulo,Roberto Pellicciari,Antimo Gioiello +8 more
TL;DR: C3-glucuronides of chenodeoxycholic acid and lithocholic acid, respectively the most abundant and potentially cytotoxic species formed in patients affected by cholestasis, behave as FXR agonists and positively regulate the gene expression of transporter proteins, the function of which is critical in human conditions related to imbalances of bile acid homeostasis.
16
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Jean-Rémy Marchand,Andrea Carotti,Daniela Passeri,Paolo Filipponi,Paride Liscio,Emidio Camaioni,Roberto Pellicciari,Antimo Gioiello,Antonio Macchiarulo +8 more
TL;DR: Fluorescence anisotropy assays support such a mechanism, providing the first experimental evidence that HYDAMTIQ, a potent PARP inhibitor with neuroprotective properties, is less potent than Olaparib to trap PARP-1/DNA complex.
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