Daniela Modena
Coventry Health Care
30 Papers
175 Citations
Daniela Modena is an academic researcher from Coventry Health Care. The author has contributed to research in topics: In vivo & Ribosome-inactivating protein. The author has an hindex of 11, co-authored 28 publications.
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Papers
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).
Antonio Furlan,Antonio Furlan,Valmen Monzani,Leonid L. Reznikov,Flavio Leoni,Gianluca Fossati,Daniela Modena,Paolo Mascagni,Charles A. Dinarello +8 more
TL;DR: It is concluded that dosing of 50 or 100 mg ITF2357 is safe in healthy humans and transiently but repeatedly reduces the production of proinflammatory cytokines without affecting production of anti inflammatory cytokines.
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Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo
Suzhao Li,Gianluca Fossati,Carlo Marchetti,Daniela Modena,Pietro Pozzi,Leonid L. Reznikov,Maria Luisa Moras,Tania Azam,Antonio Abbate,Paolo Mascagni,Charles A. Dinarello,Charles A. Dinarello +11 more
TL;DR: The data suggest that specific inhibition of HDAC8 results in reduced inflammation without cell toxicity, which is preferred for treating inflammatory diseases, with fewer side effects.
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Nucleotide sequence of cDNA coding for dianthin 30, a ribosome inactivating protein from Dianthus caryophyllus.
Giuseppe Legname,Paola Bellosta,Gianni Gromo,Daniela Modena,Jeff N. Keen,Lynne M. Roberts,J. Michael Lord +6 more
TL;DR: Rabbit antibodies raised against dianthin 30, a ribosome inactivating protein from carnation (Dianthus caryophyllus) leaves, were used to identify a full length dian thinner precursor cDNA clone from a lambda gt11 expression library.
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Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
Barbara Vergani,Sandrone Giovanni,Mattia Marchini,Ripamonti Chiara,Edoardo Cellupica,Elisabetta Galbiati,Gianluca Caprini,Pavich Gianfranco,Giulia Porro,Ilaria Rocchio,Maria Lattanzio,Pezzuto Marcello,M. Skorupska,Paola Cordella,Paolo Pagani,Pietro Pozzi,Roberta Pomarico,Daniela Modena,Flavio Leoni,Raffaella Perego,Gianluca Fossati,Christian Steinkühler,Andrea Stevenazzi +22 more
TL;DR: A new class of potent and selective HDAC6 inhibitors that bear a pentaheterocyclic central core are described, showing a remarkably low toxicity both in vitro and in vivo and are able to increase the function of regulatory T cells (Tregs) at well tolerated concentrations.
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Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Davide Agnello,Eugenio Scanziani,Mauro Di Giancamillo,Flavio Leoni,Daniela Modena,Paolo Mascagni,Martino Introna,Pietro Ghezzi,Pia Villa +8 more
TL;DR: It is found that the extent of disease suppression among the different groups of animals correlated with serum anti-hsp10 antibody levels, suggesting that immune deviation may play a role in the mechanism of disease suppressed by hsp10.
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