Daniela Malan
University of Turin
9 Papers
123 Citations
Daniela Malan is an academic researcher from University of Turin. The author has contributed to research in topics: Muscarinic acetylcholine receptor & Contractility. The author has an hindex of 9, co-authored 9 publications.
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Papers
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
Gianluca Baldanzi,Nicoletta Filigheddu,Santina Cutrupi,Filomena Catapano,Sara Bonissoni,Alberto Fubini,Daniela Malan,G. Baj,Riccarda Granata,Fabio Broglio,Mauro Papotti,Nicola Surico,Federico Bussolino,Jörgen Isgaard,Romano Deghenghi,Fabiola Sinigaglia,Maria Prat,Giampiero Muccioli,Ezio Ghigo,Andrea Graziani +19 more
TL;DR: These findings provide the first evidence that, independent of its acylation, ghrelin gene product may act as a survival factor directly on the cardiovascular system through binding to a novel, yet to be identified receptor, which is distinct from GHSR-1a.
Regulation of cardiac calcium current by NO and cGMP-modulating agents
TL;DR: It is proposed that the increase of basal ICa in guinea pig cardiomyocytes previously observed with L-NMMA depends on the removal of a tonic NO inhibition, suggesting a NO-guanylate cyclase mechanism in the basal control of ventricular calcium current.
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Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes.
TL;DR: It is suggested that peroxynitrite donors increase cardiac calcium current without the involvement of cAMP and cGMP.
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Microtubules mobility affects the modulation of L-type ICa by muscarinic and β-adrenergic agonists in guinea-pig cardiac myocytes
TL;DR: The data suggest that microtubule stabilization significantly affects the muscarinic modulation of I(Ca), by interacting with the receptor or the G-protein rather than on the intracellular signaling cascade.
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Phosphoinositide 3-kinase γ controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level
Giuseppe Alloatti,Andrea Marcantoni,Renzo Levi,Maria Pia Gallo,Lorenzo Del Sorbo,Enrico Patrucco,Laura Barberis,Daniela Malan,Ornella Azzolino,Matthias P. Wymann,Emilio Hirsch,Giuseppe Montrucchio +11 more
TL;DR: Cardiac β‐adrenergic and the muscarinic receptors control contractility and heart rate by triggering multiple signaling events involving downstream targets like the phosphoinositide 3‐kinase γ (PI3Kγ).
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