Daniela Giunciuglio
University of Genoa
19 Papers
550 Citations
Daniela Giunciuglio is an academic researcher from University of Genoa. The author has contributed to research in topics: Matrigel & Metastasis. The author has an hindex of 16, co-authored 19 publications.
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Papers
The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.
Adriana Albini,Raffaella Soldi,Daniela Giunciuglio,Enrico Giraudo,Roberto Benelli,Luca Primo,Douglas M. Noonan,Mariolina Salio,Giovanni Camussi,Wolfang Rockl,Federico Bussolino +10 more
TL;DR: It is demonstrated that HIV–1 Tat specifically binds and activates the Flk–1/kinase insert domain receptor (Flk-1/KDR), a VEGF–A tyrosine kinase receptor, and that Tat–induced angiogenesis is blocked by agents blocking the FlK–1-KDR receptor.
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Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine.
TL;DR: The data indicate that NAC affects the process of tumor‐cell invasion and metastasis, probably due to inhibition of gelatinases by its sulfhydryl group, with the possible contribution of other mechanisms, including the potent antioxidant activity of this thiol.
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Invasive phenotype of MCF10A cells overexpressing c‐Ha‐ras and c‐erbB‐2 oncogenes
Daniela Giunciuglio,Martine Culty,Gianfranco Fassina,L. Masiello,Melchiori A,G. Paglialunga,Gloria Arand,Fortunato Ciardiello,Fulvio Basolo,Erik W. Thompson,Adriana Albini +10 more
TL;DR: It is shown that oncogene‐transformed MCF10A are able to halt in the lungs of nude mice, a sign of organ colonization potential, and that erbB‐2 and Ha‐ros co‐expression can induce a more aggressive phenotype in vitro, representative of the malignancy of mammary carcinomas.
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Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA.
R. Adatia,Adriana Albini,Sebastiano Carlone,Daniela Giunciuglio,Roberto Benelli,Leonardo Santi,Douglas M. Noonan +6 more
TL;DR: The results indicate the importance of perlecan as a regulator of growth factor activity affecting the biological properties of metastatic cells, and suggest the potential use of antisense perle can DNA in anti-melanoma gene therapy approaches.
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Osteoblastic cells from rat long bone. I. Characterization of their differentiation in culture
TL;DR: The characterization for osteogenic markers alkaline phosphate, osteocalcin, and mineral deposition of osteoblast cultures derived from cells migrating out from seven-day-old rat tibia fragments, and the stimulatory effect that conditioned serum-free media from these cultures exert on the migration of endothelial cells are reported.
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