Daniela Fraccarollo
Hochschule Hannover
12 Papers
85 Citations
Daniela Fraccarollo is an academic researcher from Hochschule Hannover. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 9, co-authored 12 publications.
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Papers
Novel therapeutic approaches to post-infarction remodelling
TL;DR: This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI.
C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure.
Mahesh Appari,Astrid Breitbart,Florian Brandes,Malgorzata Szaroszyk,Natali Froese,Mortimer Korf-Klingebiel,Mona Malek Mohammadi,Andrea Grund,Gesine M. Scharf,Honghui Wang,Carolin Zwadlo,Daniela Fraccarollo,Ulrike Schrameck,Mona Nemer,G. William Wong,Hugo A. Katus,Kai C. Wollert,Oliver J. Müller,Johann Bauersachs,Joerg Heineke +19 more
TL;DR: The upregulation of CTRP9 during hypertrophic heart disease facilitates maladaptive cardiac remodeling and left ventricular dysfunction and might constitute a therapeutic target in the future.
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Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition
Daniela Fraccarollo,Paolo Galuppo,Stephanie Motschenbacher,Hartmut Ruetten,Andreas Schäfer,Johann Bauersachs +5 more
TL;DR: It is found that ataciguat stimulating sGC activity was potentiated in (myo)fibroblasts during hypoxia-induced oxidative stress and that NO/heme-independent sGC activation modulated fibroblast–cardiomyocyte crosstalk in the context of heart failure and hypoxIA.
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The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury
Stefan Frantz,Anna Adamek,Daniela Fraccarollo,J. Tillmanns,J. Widder,Charlotte Dienesch,Andreas Schäfer,A. Podolskaya,M. Held,Hartmut Ruetten,G. Ertl,Johann Bauersachs +11 more
TL;DR: Pharmacological interventions addressed to increase eNOS-derived NO production constitute a promising therapeutic approach to prevent myocardial ischemia/reperfusion injury.
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Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure
Andreas Schäfer,Daniela Fraccarollo,Stephanie Pförtsch,Elena Loch,Jonas Neuser,Christian Vogt,Johann Bauersachs +6 more
TL;DR: Chronic P2Y12-blockade with clopidogrel improved adenylyl cyclase-mediated signaling including increased AKT- and eNOS-phosphorylation contributing to improved NO-mediated vasorelaxation.
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