Daniela E. Kirwan
St George's, University of London
47 Papers
97 Citations
Daniela E. Kirwan is an academic researcher from St George's, University of London. The author has contributed to research in topics: Tuberculosis & Medicine. The author has an hindex of 12, co-authored 38 publications. Previous affiliations of Daniela E. Kirwan include Imperial College London & St George's Hospital.
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Papers
Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity
Luisa Paris,Ruben Magni,Fatima Zaidi,Robyn P. Araujo,Neal Saini,Michael G. Harpole,Jorge Coronel,Daniela E. Kirwan,Hannah E. Steinberg,Robert H. Gilman,Emanuel F. Petricoin,Roberto Nisini,Alessandra Luchini,Lance A. Liotta +13 more
TL;DR: Urinary LAM was elevated in patients with a higher mycobacterial burden, a higher proportion of weight loss, or cough, and could also be used to detect cytokines and other antigens present in low concentrations in urine, demonstrating the versatility of the technology as a method to detect and monitor infections.
110
Dynamics of Cough Frequency in Adults Undergoing Treatment for Pulmonary Tuberculosis.
Alvaro Proaño,Marjory A. Bravard,Marjory A. Bravard,José W. López,Gwenyth O. Lee,David P. Bui,Sumona Datta,Sumona Datta,Germán Comina,Germán Comina,Mirko Zimic,Jorge Coronel,Luz Caviedes,José L. Cabrera,Antonio Salas,Eduardo Ticona,Nancy M. Vu,Daniela E. Kirwan,Maria-Cristina I. Loader,Jon S. Friedland,David Moore,David Moore,Carlton A. Evans,Carlton A. Evans,Brian H. Tracey,Robert H. Gilman,Robert H. Gilman +26 more
TL;DR: This study provides novel information on the circadian cycle of cough frequency and risk factors for increased cough frequency as well as associations with mycobacterial load and treatment.
57
Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections
Henry M. Staines,Daniela E. Kirwan,David J Clark,Emily R. Adams,Yolanda Augustin,Rachel L Byrne,Michael Cocozza,Ana I Cubas-Atienza,Luis E. Cuevas,Martina Cusinato,Benedict M O Davies,Mark M. Davis,Paul A. Davis,Annelyse Duvoix,Nicholas M Eckersley,Daniel M. Forton,Alice J. Fraser,Gala Garrod,Linda Hadcocks,Qinxue Hu,Michael H. Johnson,Grant A Kay,Kesja Klekotko,Zawditu Lewis,Josephine Mensah-Kane,Stefanie Menzies,Irene M. Monahan,Catherine M. Moore,Gerhard Nebe-von-Caron,Sophie I Owen,Chris Sainter,Amadou A. Sall,James Schouten,Christopher T Williams,John T. Wilkins,Kevin Woolston,Joseph R Fitchett,Sanjeev Krishna,Tim Planche +38 more
TL;DR: Dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR are reported and higher antibody responses are associated with symptomatic disease, older age, ethnicity, increased co-morbidity and higher inflammatory markers such as C Reactive Protein.
Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.
Mirko Zimic,Patricia Fuentes,Robert H. Gilman,Robert H. Gilman,Andres H. Gutierrez,Daniela E. Kirwan,Patricia Sheen +6 more
TL;DR: This finding suggests that mechanisms other than pncA mutations (reduction of pyrazinamidase activity) are also implicated in pyraz inamide resistance, and that pyrazinoic acid efflux rate acts as a better proxy forpyrazinamide resistance than the presence of pNCA mutations.
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Platelet Activation and the Immune Response to Tuberculosis.
TL;DR: A review of the growing evidence implicating platelets in TB immunopathology can be found in this article, where the authors consider the use of targeted anti-platelet agents in the treatment of TB due to growing interest in developing host-directed therapies to limit tissue damage and improve treatment outcomes.