Daniela C. Kroy
RWTH Aachen University
44 Papers
109 Citations
Daniela C. Kroy is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Steatohepatitis & Liver transplantation. The author has an hindex of 17, co-authored 40 publications.
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Papers
Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030
Chris Estes,Quentin M. Anstee,María Teresa Arias-Loste,Heike Bantel,Stefano Bellentani,Joan Caballería,Massimo Colombo,Antonio Craxì,Javier Crespo,Christopher P. Day,Yuichiro Eguchi,Andreas Geier,Loreta A. Kondili,Daniela C. Kroy,Jeffrey V. Lazarus,Rohit Loomba,Michael P. Manns,Giulio Marchesini,Atsushi Nakajima,Francesco Negro,Salvatore Petta,V. Ratziu,Manuel Romero-Gómez,Arun J. Sanyal,Jörn M. Schattenberg,Frank Tacke,Junko Tanaka,Christian Trautwein,Lai Wei,Stefan Zeuzem,Homie Razavi +30 more
TL;DR: NAFLD and NASH represent a large and growing public health problem and efforts to understand this epidemic and to mitigate the disease burden are needed, if obesity and DM continue to increase at current and historical rates.
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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Mohsen Malehmir,Dominik Pfister,Suchira Gallage,Marta Szydlowska,Donato Inverso,Donato Inverso,Elena Kotsiliti,Elena Kotsiliti,Valentina Leone,Moritz Peiseler,Bas G.J. Surewaard,Dominik Rath,Adnan Ali,Monika Julia Wolf,Hannah K. Drescher,Marc E. Healy,Daniel Dauch,Daniela C. Kroy,Oliver Krenkel,Marlene Kohlhepp,Thomas Engleitner,Thomas Engleitner,Alexander Olkus,Alexander Olkus,Tjeerd P. Sijmonsma,Julia Volz,Carsten Deppermann,David Stegner,Patrick M. Helbling,César Nombela-Arrieta,Anahita Rafiei,Martina Hinterleitner,Marcel Rall,Florian Baku,Oliver Borst,Caroline L. Wilson,Jack Leslie,Tracy O'Connor,Christopher J. Weston,David H. Adams,Lozan Sheriff,Ana Teijeiro,Marco Prinz,Ruzhica Bogeska,Natasha S Anstee,Malte N. Bongers,Mike Notohamiprodjo,Tobias Geisler,Dominic J. Withers,Jerry Ware,Derek A. Mann,Hellmut G. Augustin,Hellmut G. Augustin,Alexandros Vegiopoulos,Michael D. Milsom,Adam J. Rose,Patricia F. Lalor,Josep M. Llovet,Josep M. Llovet,Josep M. Llovet,Roser Pinyol,Frank Tacke,Roland Rad,Roland Rad,Matthias S. Matter,Nabil Djouder,Paul Kubes,Percy A. Knolle,Kristian Unger,Lars Zender,Lars Zender,Bernhard Nieswandt,Meinrad Gawaz,Achim Weber,Mathias Heikenwalder,Mathias Heikenwalder +75 more
TL;DR: It is shown that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance, offering a potential approach to treat non-alcoholic steatohepatitis and prevent subsequent progression to hepatocellular carcinoma.
Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice.
Daniela C. Kroy,Naiara Beraza,Darjus F. Tschaharganeh,Leif E. Sander,S Erschfeld,Arne Giebeler,Christian Liedtke,Hermann E. Wasmuth,Christian Trautwein,Konrad L. Streetz +9 more
TL;DR: The presented model allows one to further dissect the role of IL‐6/gp130‐type signaling in hepatocytes during fatty liver degeneration to define new therapeutic targets in metabolic liver diseases.
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Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice
Daniela C. Kroy,Fabienne Schumacher,Pierluigi Ramadori,Maximilian Hatting,Ina Bergheim,Nikolaus Gassler,Mark V. Boekschoten,Michael Müller,Konrad L. Streetz,Christian Trautwein +9 more
TL;DR: Gene array analysis demonstrated that genes involved in fatty acid metabolism were strongly upregulated in c-MetΔ(hepa) livers correlating with higher amounts of hepatic free fatty acids, which correlated with an enhanced progression of liver fibrosis.
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Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis
Werner Plum,Darjus F. Tschaharganeh,Daniela C. Kroy,Eva Corsten,S Erschfeld,Uta Dierssen,Hermann E. Wasmuth,Christian Trautwein,Konrad L. Streetz +8 more
TL;DR: It is demonstrated that gp130/STAT signaling in hepatocytes provides protection in a cholestatic hepatitis mouse model and protects from apoptosis and tissue injury, which subsequently reduce oval cell activation and prevent fibrosis progression.
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