Daniela Bakula
University of Tübingen
21 Papers
86 Citations
Daniela Bakula is an academic researcher from University of Tübingen. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Daniela Bakula include Max Planck Society.
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Papers
WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
Daniela Bakula,Daniela Bakula,Amelie J. Müller,Amelie J. Müller,Theresia Zuleger,Zsuzsanna Takacs,Zsuzsanna Takacs,Mirita Franz-Wachtel,Ann-Katrin Thost,Daniel Brigger,Mario P. Tschan,Tancred Frickey,Horst Robenek,Boris Macek,Tassula Proikas-Cezanne,Tassula Proikas-Cezanne +15 more
TL;DR: WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the Ptd Insurance 3-phosphate effector function of WIPi1-WIPi2 at nascent autophagosomes, reports report.
203
Nuclear morphology is a deep learning biomarker of cellular senescence
Indra Heckenbach,Garik Mkrtchyan,Michael ben Ezra,Daniela Bakula,Jakob B. Madsen,Malte H. Nielsen,Denise Oró,Brenna Osborne,Anthony J. Covarrubias,M. Laura Idda,Myriam Gorospe,Laust Hvas Mortensen,Eric Verdin,Rudi G. J. Westendorp,Morten Scheibye-Knudsen +14 more
TL;DR: Using neural networks, the authors predict senescence from the nuclear morphology of human fibroblasts with up to 95% accuracy, and investigate murine astrocytes, murine neurons, and fibroblast cells with premature aging in culture.
Modulation of intracellular calcium homeostasis blocks autophagosome formation.
Nikolai Engedal,Maria Lyngaas Torgersen,Ingrid Jenny Guldvik,Stefan J Barfeld,Daniela Bakula,Frank Sætre,Linda Korseberg Hagen,John B. Patterson,Tassula Proikas-Cezanne,Per Ottar Seglen,Anne Simonsen,Ian G. Mills +11 more
TL;DR: It is proposed that local perturbations in intracellular calcium levels can exert inhibitory effects on autophagy at the stage of autophagosome expansion and closure.
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Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells
Simon G. Pfisterer,Daniela Bakula,Tancred Frickey,Alice Cezanne,Daniel Brigger,Mario P. Tschan,Horst Robenek,Tassula Proikas-Cezanne +7 more
TL;DR: It is demonstrated that two ATGs, human Atg2A and Atg14L, colocalize at cytoplasmic lipid droplets (LDs) and are functionally involved in controlling the number and size of LDs in human tumor cell lines and also in lipid metabolism.
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