Daniel T Johnson
University of California, San Diego
14 Papers
27 Citations
Daniel T Johnson is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Lens (optics) & Fusion gene. The author has an hindex of 5, co-authored 14 publications.
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Papers
Destabilizing mutations encode nongenetic variation that drives evolutionary innovation
Katherine L. Petrie,Katherine L. Petrie,Nathan David Palmer,Daniel T Johnson,Sarah J. Medina,Stephanie J. Yan,Victor Li,Alita R. Burmeister,Justin R. Meyer +8 more
TL;DR: It is proposed that cases where a single genotype can manifest as multiple phenotypes may be more common than previously expected and offer a general mechanism for evolutionary innovation.
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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy.
Daniel T Johnson,Jiarong Zhou,Ashley V. Kroll,Ronnie H. Fang,Ming Yan,Crystal Xiao,Xiufen Chen,Justin Kline,Liangfang Zhang,Dong-Er Zhang +9 more
TL;DR: In this paper, an AML cell membrane-coated nanoparticle (AMCNP) vaccine platform was proposed, in which immune-stimulatory adjuvant-loaded nanoparticles are coated with leukemic cell membrane material.
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Fluidic lens laparoscopic zoom camera for minimally invasive surgery.
Frank S. Tsai,Daniel T Johnson,Cameron S. Francis,Sung Hwan Cho,Wen Qiao,Ashkan Arianpour,Yoav Mintz,Santiago Horgan,Mark A. Talamini,Yu-Hwa Lo +9 more
TL;DR: A miniaturized laparoscopic zoom camera that is 17 mm long, has >4X optical zoom, and works under 300 lux is developed, suitable for advancing minimally invasive surgery.
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Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation
Samuel A Stoner,Ming Yan,Katherine Tin Heng Liu,Kei-ichiro Arimoto,Takahiro Shima,Huan You Wang,Daniel T Johnson,Rafael Bejar,Catriona Jamieson,Kun-Liang Guan,Dong-Er Zhang +10 more
TL;DR: Heterozygous Hippo kinase MST1 (STK4) is identified as having a central role in the biology of del(20q)-associated hematologic malignancies and a novel molecular basis of adverse MPN progression that may be therapeutically exploitable via IRAK1 inhibition is revealed.
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MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3'UTR.
TL;DR: In this paper, the authors examined the regulation of AML1-ETO via the 3'Untranslated Regions (UTR) of the ETO gene and found that 3'UTR is post-transcriptionally regulated by let-7b microRNA.