Daniel Sutton
AstraZeneca
18 Papers
4 Citations
Daniel Sutton is an academic researcher from AstraZeneca. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Daniel Sutton include Novartis.
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Papers
AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Alice E. Pollard,Alice E. Pollard,Luís Martins,Phillip J. Muckett,Sanjay Khadayate,Aurélie Bornot,Maryam Clausen,Therese Admyre,Mikael Bjursell,Rebeca Fiadeiro,Laura A. B. Wilson,Chad Whilding,Vassilios N. Kotiadis,Michael R. Duchen,Daniel Sutton,Lucy Penfold,Alessandro Sardini,Mohammad Bohlooly-Y,David M. Smith,Jon Read,Michael A. Snowden,Angela Woods,David Carling +22 more
- 25 Feb 2019
TL;DR: It is suggested that AMPK activation enriches, or leads to the emergence of, a population of subcutaneous white adipocytes that produce heat via Ucp1-independent uncoupling of adenosine triphosphate (ATP) production on a HFD.
The next-generation oral selective estrogen receptor degrader camizestrant (AZD9833) suppresses ER+ breast cancer growth and overcomes endocrine and CDK4/6 inhibitor resistance.
Mandy Lawson,Natalie Ison Cureton,Susana Ros,Azadeh Cheraghchi-Bashi-Astaneh,Jelena Urosevic,Sophie D'Arcy,Oona Delpuech,Michelle DuPont,David I Fisher,Eric T Gangl,Hilary Lewis,Dawn Trueman,Neha Wali,S. C. Williamson,Jennifer I. Moss,Elodie Montaudon,Heloise Derrien,Elisabetta Marangoni,Ricardo J Miragaia,Sladjana Gagrica,Pablo Morentin Gutierrez,T. Moss,Gareth A Maglennon,Daniel Sutton,Radoslaw Polanski,Alan Rosen,Jonathan Cairns,Pei Zhang,Mònica Sánchez-Guixé,Violeta Serra,Susan E. Critchlow,James S Scott,Justin P.O. Lindemann,Simon T. Barry,Teresa Klinowska,Christopher J. Morrow,Larissa S. Carnevalli +36 more
TL;DR: Camizestrant (AZD9833) exhibits potent anti-tumor activity in ER+ breast cancer models and overcomes resistance to endocrine and CDK4/6 inhibitor therapy.
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Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution
Nicole Strittmatter,Jennifer I. Moss,Alan M. Race,Daniel Sutton,Jaime Rodriguez Canales,Stephanie Ling,Edmond Wong,Joanne Wilson,Aaron J. Smith,C. Howes,Josephine Bunch,Simon T. Barry,Richard J. A. Goodwin,Marianne Ashford +13 more
TL;DR: A new multi-modal imaging solution offers researchers a better understanding of drug and nanocarrier distribution in complex tissues and enables data-driven drug carrier design.
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Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Lorna Hopcroft,Eleanor M. Wigmore,SC Williamson,Susana Ros,Cath Eberlein,Jennifer I. Moss,Jelena Urosevic,Larissa S. Carnevalli,Sara Talbot,Lauren Bradshaw,Catherine Blaker,Sreeharsha Gunda,Venetia Owenson,Scott P. Hoffman,Daniel Sutton,Stewart Jones,Richard J. A. Goodwin,Brandon S. Willis,Claire Rooney,E. DeBruin,Simon T. Barry +20 more
TL;DR: Findings demonstrate that simultaneous inhibition of AKT and ER signalling can be effective in models representing palbociclib resistance despite changes in pathway dependency and was effective in vivo in palbokiclib-resistant PDX models.
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Method to Investigate the Distribution of Water-Soluble Drug-Delivery Systems in Fresh Frozen Tissues Using Imaging Mass Cytometry.
Nicole Strittmatter,Richard M. England,Alan M. Race,Daniel Sutton,Jennifer I. Moss,Gareth Maglennon,Stephanie Ling,Edmond Wong,Jonathan A. Rose,Ian Purvis,Ruth Macdonald,Simon T. Barry,Marianne Ashford,Richard J. A. Goodwin,Richard J. A. Goodwin +14 more
TL;DR: In this article, a water-soluble polysarcosine-modified dendrimer drug-delivery system (S-Dends) was used to perform IMC experiments on a water soluble poly-solvable dendricer drug delivery system.
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