Daniel Smrz
Charles University in Prague
43 Papers
108 Citations
Daniel Smrz is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Immune system & Immunotherapy. The author has an hindex of 9, co-authored 28 publications. Previous affiliations of Daniel Smrz include National Institutes of Health & Academy of Sciences of the Czech Republic.
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Papers
The TRAIL in the Treatment of Human Cancer: An Update on Clinical Trials.
Martin Snajdauf,Klara Havlova,Jiri Vachtenheim,Andrej Ozaniak,Robert Lischke,Jirina Bartunkova,Daniel Smrz,Zuzana Strizova +7 more
TL;DR: A review of the most promising TRAIL-based clinical trials and their therapeutic strategies is presented in this article, where the current status of all TRAILbased monotherapies and combination therapies that have reached phase II and phase III clinical trials in humans.
The WNT/β-catenin signaling inhibitor XAV939 enhances the elimination of LNCaP and PC-3 prostate cancer cells by prostate cancer patient lymphocytes in vitro.
Dmitry Stakheev,Pavla Taborska,Zuzana Strizova,Michal Podrazil,Jirina Bartunkova,Daniel Smrz +5 more
TL;DR: It was found that 5 µM XAV939 inhibited β-catenin translocation to the nucleus in LNCaP cells and CD4+ BRPCa lymphocytes without affecting their proliferation and viability.
Engagement of Phospholipid Scramblase 1 in Activated Cells IMPLICATION FOR PHOSPHATIDYLSERINE EXTERNALIZATION AND EXOCYTOSIS
TL;DR: The combined data indicate that changes in the topography of PLSCR1 and its tyrosine phosphorylation, PS externalization, and exocytosis are independent phenomena that could be distinguished by employing specific conditions of activation.
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Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production.
Araceli Tobío,Geethani Bandara,Denise A. Morris,Do-Kyun Kim,Michael P. O'Connell,Hirsh D. Komarow,Melody C. Carter,Daniel Smrz,Dean D. Metcalfe,Ana Olivera +9 more
TL;DR: A role for mast cells and D816V-KIT activity in IL-6 dysregulation in mastocytosis is supported and insights into the intracellular mechanisms are provided.
The Role of miR-155 in Antitumor Immunity
TL;DR: In this article , the authors provide an overview of miR-155 function in distinct immune cell populations and describe how the miR155-mediated regulation can impact the process of cancer immunoediting.