Daniel Smeets
Ludwig Maximilian University of Munich
7 Papers
Daniel Smeets is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chromatin & XIST. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Daniel Smeets include University of Oxford.
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Papers
The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments.
Thomas Cremer,Marion Cremer,Barbara Hübner,Hilmar Strickfaden,Daniel Smeets,Jens Popken,Michael Sterr,Yolanda Markaki,Karsten Rippe,Christoph Cremer +9 more
TL;DR: A model of the underlying functional nuclear organization derived mostly from electron and super‐resolved fluorescence microscopy studies is discussed, suggesting that nuclear architecture resembles a random obstacle network for diffusing proteins.
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Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy
Andrea Cerase,Daniel Smeets,Y. Amy Tang,Michal R. Gdula,Felix Kraus,Mikhail Spivakov,Benoit Moindrot,Marion Leleu,Anna Tattermusch,Justin Demmerle,Tatyana B. Nesterova,Catherine M. Green,Arie P. Otte,Lothar Schermelleh,Neil Brockdorff +14 more
TL;DR: It is revealed that Xist-mediated recruitment of polycomb repressors does not correlate well with gene silencing and, moreover, that using 3D-SIM, polycomb proteins and Xist RNA show significant spatial separation, which challenge prevailing models and prompt a reappraisal of the role of XistRNA in polycomb recruitment.
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression
Kajan Ratnakumar,Luis F. Duarte,Gary LeRoy,Dan Hasson,Daniel Smeets,Chiara Vardabasso,Clemens Bönisch,Tianying Zeng,Bin Xiang,David Y. Zhang,Haitao Li,Xiaowo Wang,Sandra B. Hake,Lothar Schermelleh,Benjamin A. Garcia,Emily Bernstein +15 more
TL;DR: The SWI/SNF helicase ATRX (α-thalassemia/MR, X-linked) is identified as a novel macroH2A-interacting protein that acts as a negative regulator of macroH 2A's chromatin association.
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
Daniel Smeets,Daniel Smeets,Yolanda Markaki,Volker Schmid,Felix Kraus,Felix Kraus,Anna Tattermusch,Andrea Cerase,Michael Sterr,Susanne Fiedler,Justin Demmerle,Jens Popken,Heinrich Leonhardt,Neil Brockdorff,Thomas Cremer,Lothar Schermelleh,Lothar Schermelleh,Marion Cremer +17 more
TL;DR: 3D-SIM provides experimental evidence for profound differences between the functional architecture of transcriptionally active CTs and the Barr body, and proposes that the PR and macromolecular complexes in IC channels together form the transcriptionally permissive active nuclear compartment (ANC).