Daniel Saroff
Harvard University
6 Papers
19 Citations
Daniel Saroff is an academic researcher from Harvard University. The author has contributed to research in topics: Choline acetyltransferase & Motor neuron. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Daniel Saroff include Beth Israel Deaconess Medical Center.
Chat about Author
Papers
Ventral and dorsal horn acetylcholinesterase neurons are maintained in organotypic cultures of postnatal rat spinal cord explants
John R. Delfs,John R. Delfs,Judith Friend,Judith Friend,Shinji Ishimoto,Shinji Ishimoto,Daniel Saroff,Daniel Saroff +7 more
TL;DR: Transverse sections of postnatal rat spinal cord have been cultured using the organotypic roller tube method to provide an attractive system for studies of survival, morphology, growth and differentiation of mammalian ventral horn neurons in vitro.
50
Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity.
TL;DR: The observations demonstrate that α-motor neurons are considerably more sensitive to KA and QUIS than to NMDA toxicity, demonstrating that the proposed excitotoxic mechanism of ALS, therefore, is most likely mediated through non-NMDA glutamate receptors.
40
Modification of the aerobic cytotoxicity of etanidazole
Sanjeewani T. Palayoor,Edward A. Bump,Kamal Malaker,R. E. Langley,Daniel Saroff,John R. Delfs,Selwyn J. Hurwitz,Selwyn J. Hurwitz,C. Norman Coleman +8 more
TL;DR: The results suggest that it might be possible to modify the neurotoxicity of etanidazole with agents that would not be expected to interfere with the tumoricidal action of radiation plus etanodazole.
10
Effects of NMDA and its antagonists on ventral horn cholinergic neurons in organotypic roller tube spinal cord cultures
John R. Delfs,John R. Delfs,Daniel Saroff,Daniel Saroff,Y. Nishida,Y. Nishida,Judith Friend,Changiz Geula,Changiz Geula +8 more
TL;DR: The results indicate that NMDA and its antagonists exert powerful toxic effects on ventral horn cholinergic neurons, however, the largecholinergic α-motoneurons appear to be relatively immune to these toxic effects.
9
•Journal Article
Effect of BSO and etanidazole on neurofilament degradation in neonatal rat spinal cord cultures.
Sanjeewani T. Palayoor,Edward A. Bump,Daniel Saroff,J. R. Delfs,Changiz Geula,L. Menton-Brennan,Selwyn J. Hurwitz,C. N. Coleman,Mary Ann Stevenson +8 more
TL;DR: The purpose of the present study was to develop the neurofilament degradation assay in an organotypic spinal cord culture system with the goal of developing strategies for optimising sensitiser efficacy as well as ameliorating nitroimidazole-induced neurotoxicity.